Publications: Whiley, Luke

Journal Article

Masuda, R., Lodge, S., Whiley, L.ORCID: 0000-0002-9088-4799, Gray, N., Lawler, N., Nitschke, P., Bong, S-H, Kimhofer, T., Loo, R.L., Boughton, B.ORCID: 0000-0001-6342-9814, Zeng, A.X., Hall, D., Schaefer, H., Spraul, M., Dwivedi, G., Yeap, B.B., Diercks, T., Bernardo-Seisdedos, G., Mato, J.M., Lindon, J.C., Holmes, E., Millet, O., Wist, J. and Nicholson, J.K. (2022) Exploration of human serum lipoprotein supramolecular phospholipids using statistical heterospectroscopy in n-Dimensions (SHY-n): Identification of potential cardiovascular risk biomarkers related to SARS-CoV-2 infection. Analytical Chemistry, 94 (10). pp. 4426-4436.

Anyaegbu, C.C., Szemray, H., Hellewell, S.C., Lawler, N.G., Leggett, K., Bartlett, C., Lins, B., McGonigle, T., Papini, M., Anderton, R.S., Whiley, L.ORCID: 0000-0002-9088-4799 and Fitzgerald, M. (2022) Plasma lipid profiles change with increasing numbers of mild traumatic brain injuries in rats. Metabolites, 12 (4). Article 322.

Albreht, A., Hussain, H., Jiménez, B., Yuen, A.H.Y., Whiley, L.ORCID: 0000-0002-9088-4799, Witt, M., Lewis, M.R. and Chekmeneva, E. (2022) Structure elucidation and mitigation of endogenous interferences in LC-MS-Based metabolic profiling of urine. Analytical Chemistry, 94 (3). pp. 1760-1768.

Yeung, K.T.D., Penney, N., Whiley, L.ORCID: 0000-0002-9088-4799, Ashrafian, H., Lewis, M.R., Purkayastha, S., Darzi, A. and Holmes, E. (2022) The impact of bariatric surgery on serum tryptophan–kynurenine pathway metabolites. Scientific Reports, 12 (1). Art. 294.

Gray, N., Lawler, N., Zeng, A., Ryan, M., Bong, S-H, Boughton, B.ORCID: 0000-0001-6342-9814, Bizkarguenaga, M., Bruzzone, C., Embade, N., Wist, J., Holmes, E., Millet, O., Nicholson, J. and Whiley, L.ORCID: 0000-0002-9088-4799 (2021) Diagnostic potential of the plasma lipidome in infectious disease: Application to acute SARS-CoV-2 infection. Metabolites, 11 (7). Article 467.

Holmes, E., Wist, J., Masuda, R., Lodge, S., Nitschke, P., Kimhofer, T., Loo, R.L., Begum, S., Boughton, B.ORCID: 0000-0001-6342-9814, Yang, R.ORCID: 0000-0003-2563-2015, Morillon, A-C, Chin, S-T, Hall, D., Ryan, M., Bong, S-H, Gay, M., Edgar, D.W., Lindon, J.C., Richards, T., Yeap, B.B., Pettersson, S., Spraul, M., Schaefer, H., Lawler, N.G., Gray, N., Whiley, L.ORCID: 0000-0002-9088-4799 and Nicholson, J.K. (2021) Incomplete systemic recovery and metabolic phenoreversion in Post-Acute-Phase nonhospitalized COVID-19 Patients: Implications for assessment of Post-Acute COVID-19 syndrome. Journal of Proteome Research, 20 (6). pp. 3315-3329.

Whiley, L.ORCID: 0000-0002-9088-4799, Chappell, K.E., D’Hondt, E., Lewis, M.R., Jiménez, B., Snowden, S.G., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Swann, J.R., Hye, A., Lovestone, S., Legido-Quigley, C. and Holmes, E. (2021) Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease. Alzheimer's Research & Therapy, 13 (1). Art. 20.

Lawler, N.G., Gray, N., Kimhofer, T., Boughton, B.ORCID: 0000-0001-6342-9814, Gay, M., Yang, R.ORCID: 0000-0003-2563-2015, Morillon, A-C, Chin, S-T, Ryan, M., Begum, S., Bong, S-H, Coudert, J.D., Edgar, D., Raby, E., Pettersson, S., Richards, T., Holmes, E., Whiley, L.ORCID: 0000-0002-9088-4799 and Nicholson, J.K. (2021) Systemic perturbations in amine and kynurenine metabolism associated with acute SARS-CoV-2 infection and inflammatory cytokine responses. Journal of Proteome Research, 20 (5). pp. 2796-2811.

Wei, G.Z., Martin, K.A., Xing, P.Y., Agrawal, R., Whiley, L.ORCID: 0000-0002-9088-4799, Wood, T.K., Hejndorf, S., Ng, Y.Z., Low, J.Z.Y., Rossant, J., Nechanitzky, R., Holmes, E., Nicholson, J.K., Tan, E-K, Matthews, P.M. and Pettersson, S. (2021) Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor. Proceedings of the National Academy of Sciences, 118 (27). Art. e2021091118.

Gray, N., Lawler, N.G., Yang, R.ORCID: 0000-0003-2563-2015, Morillon, A-C, Gay, M.C.L., Bong, S-H, Holmes, E., Nicholson, J.K. and Whiley, L.ORCID: 0000-0002-9088-4799 (2021) A simultaneous exploratory and quantitative amino acid and biogenic amine metabolic profiling platform for rapid disease phenotyping via UPLC-QToF-MS. Talanta, 223 (Pt. 2). Article 121872.

Letertre, M.P.M., Myridakis, A., Whiley, L.ORCID: 0000-0002-9088-4799, Camuzeaux, S., Lewis, M.R., Chappell, K.E., Thaikkatil, A., Dumas, M-E, Nicholson, J.K., Swann, J.R. and Wilson, I.D. (2021) A targeted ultra performance liquid chromatography – Tandem mass spectrometric assay for tyrosine and metabolites in urine and plasma: Application to the effects of antibiotics on mice. Journal of Chromatography B, 1164 . Art. 122511.

Kimhofer, T., Lodge, S., Whiley, L.ORCID: 0000-0002-9088-4799, Gray, N., Loo, R.L., Lawler, N.G., Nitschke, P., Bong, S-H, Morrison, D.L., Begum, S., Richards, T., Yeap, B.B., Smith, C., Smith, K.G.C., Holmes, E. and Nicholson, J.K. (2020) Integrative modeling of quantitative plasma lipoprotein, metabolic, and amino acid data reveals a multiorgan pathological signature of SARS-CoV-2 infection. Journal of Proteome Research, 19 (11). pp. 4442-4454.

Loo, R.L., Lodge, S., Kimhofer, T., Bong, S-H, Begum, S., Whiley, L.ORCID: 0000-0002-9088-4799, Gray, N., Lindon, J.C., Nitschke, P., Lawler, N.G., Schäfer, H., Spraul, M., Richards, T., Nicholson, J.K. and Holmes, E. (2020) Quantitative in-vitro diagnostic NMR spectroscopy for lipoprotein and metabolite measurements in plasma and serum: Recommendations for analytical artifact minimization with special reference to COVID-19/SARS-CoV-2 Samples. Journal of Proteome Research, 19 (11). pp. 4428-4441.

Kurbatova, N., Garg, M., Whiley, L.ORCID: 0000-0002-9088-4799, Chekmeneva, E., Jiménez, B., Gómez-Romero, M., Pearce, J., Kimhofer, T., D’Hondt, E., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Aarsland, D., Nevado-Holgado, A., Liu, B., Snowden, S., Proitsi, P., Ashton, N.J., Hye, A., Legido-Quigley, C., Lewis, M.R., Nicholson, J.K., Holmes, E., Brazma, A. and Lovestone, S. (2020) Urinary metabolic phenotyping for Alzheimer’s disease. Scientific Reports, 10 (1). Art. 21745.

Yeung, D., Penney, N., Whiley, L.ORCID: 0000-0002-9088-4799, Ashrafian, H., Purkayastha, S., Holmes, E. and Darzi, A. (2019) A389 Kynurenic Acid- A clue for different mechanisms of action in Bariatric surgery? Surgery for Obesity and Related Diseases, 15 (10). S158.

Whiley, L.ORCID: 0000-0002-9088-4799, Chekmeneva, E., Berry, D.J., Jiménez, B., Yuen, A.H.Y., Salam, A., Hussain, H., Witt, M., Takats, Z., Nicholson, J. and Lewis, M.R. (2019) Systematic isolation and structure elucidation of urinary metabolites optimized for the analytical-scale molecular profiling laboratory. Analytical Chemistry, 91 (14). pp. 8873-8882.

Whiley, L.ORCID: 0000-0002-9088-4799, Nye, L.C., Grant, I., Andreas, N., Chappell, K.E., Sarafian, M.H., Misra, R., Plumb, R.S., Lewis, M.R., Nicholson, J.K., Holmes, E., Swann, J.R. and Wilson, I.D. (2019) Ultrahigh-performance liquid chromatography tandem mass spectrometry with electrospray ionization quantification of tryptophan metabolites and markers of gut health in serum and plasma — Application to clinical and epidemiology cohorts. Analytical Chemistry, 91 (8). pp. 5207-5216.

Domingo-Almenara, X., Montenegro-Burke, J.R., Ivanisevic, J., Thomas, A., Sidibé, J., Teav, T., Guijas, C., Aisporna, A.E., Rinehart, D., Hoang, L., Nordström, A., Gómez-Romero, M., Whiley, L.ORCID: 0000-0002-9088-4799, Lewis, M.R., Nicholson, J.K., Benton, H.P. and Siuzdak, G. (2018) XCMS-MRM and METLIN-MRM: A cloud library and public resource for targeted analysis of small molecules. Nature Methods, 15 (9). pp. 681-684.

Kim, M., Nevado-Holgado, A., Whiley, L.ORCID: 0000-0002-9088-4799, Snowden, S.G., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Thambisetty, M., Dobson, R.J.B., Powell, J.F., Lupton, M.K., Simmons, A., Velayudhan, L., Lovestone, S., Proitsi, P., Legido-Quigley, C., Mielke, M. and Martinez, P. (2017) Association between plasma ceramides and hosphatidylcholines and hippocampal brain volume in late onset Alzheimer's disease. Journal of Alzheimer's Disease, 60 (3). pp. 809-817.

Proitsi, P., Kim, M., Whiley, L.ORCID: 0000-0002-9088-4799, Simmons, A., Sattlecker, M., Velayudhan, L., Lupton, M.K., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Powell, J.F., Dobson, R.J.B. and Legido-Quigley, C. (2017) Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis. Alzheimer's & Dementia, 13 (2). pp. 140-151.

Westwood, S., Hye, A., Lleó, A., Nevado-Holgado, A.J., Baird, A.L., Wallin, A., Leslie, A., Jimenez, B., Liu, B.Y., Legido-Quigley, C., Dima, D., Ruvolo, D., Holmes, E., D'Hondt, E., Westman, E., Barkhof, F., Frisoni, G.B., Zetterberg, H., Bos, I., Pearce, J., Streffer, J., Molinuevo, J.L., Popp, J., Bertram, L., Whiley, L.ORCID: 0000-0002-9088-4799, Maslen, L., Gómez-Romero, M., David, M., Lewis, M., Kurbatova, N., Ashton, N.J., Voyle, N., Kowalczyk, O., Martinez-Lage, P., Proitsi, P., Scheltens, P., Visser, P.J., Dobson, R.J.B., Vandenberghe, R., Engelborghs, S., Vos, S.J.B., Snowden, S.G., Athersuch, T., Ashby, T., Kimhofer, T., Verachtert, W. and Lovestone, S. (2017) Discovery and validation of multimodal biomarker signatures relating to Alzheimer's disease pathology and progression. Alzheimer's & Dementia, 13 (7). P174-P175.

Price, M.E., Docx, C.J., Rice, H., Fairhall, S.J., Poole, S.J.C., Bird, M., Whiley, L.ORCID: 0000-0002-9088-4799, Flint, D.P., Green, A.C., Timperley, C.M. and Tattersall, J.E.H. (2016) Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig. Toxicology Letters, 244 . pp. 154-160.

Proitsi, P., Min, K., Whiley, L.ORCID: 0000-0002-9088-4799, Newhouse, S., Johnston, C., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Sham, P., Lovestone, S., Powell, J.F., Quigley, C.L. and Dobson, R.J.B. (2015) O4-05-05: Genetic influences on metabolite levels in Alzheimer's disease. Alzheimer's & Dementia, 11 (7S_Part_6). P279-P280.

Proitsi, P., Kim, M., Whiley, L.ORCID: 0000-0002-9088-4799, Pritchard, M., Leung, R., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Sham, P., Lovestone, S., Powell, J.F., Dobson, R.J.B. and Legido-Quigley, C. (2015) Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease. Translational Psychiatry, 5 . e494.

Whiley, L.ORCID: 0000-0002-9088-4799, Sen, A., Heaton, J., Proitsi, P., García-Gómez, D., Leung, R., Smith, N., Thambisetty, M., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Lovestone, S. and Legido-Quigley, C. (2014) Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease. Neurobiology of Aging, 35 (2). pp. 271-278.

Godzien, J., Ciborowski, M., Whiley, L.ORCID: 0000-0002-9088-4799, Legido-Quigley, C., Ruperez, F.J. and Barbas, C. (2013) In-vial dual extraction liquid chromatography coupled to mass spectrometry applied to streptozotocin-treated diabetic rats. Tips and pitfalls of the method. Journal of Chromatography A, 1304 . pp. 52-60.

Sen, A., Wang, Y., Chiu, K., Whiley, L.ORCID: 0000-0002-9088-4799, Cowan, D., Chang, R.C-C and Legido-Quigley, C. (2013) Metabolic phenotype of the healthy rodent model using in-vial extraction of dried serum, urine, and cerebrospinal fluid spots. Analytical Chemistry, 85 (15). pp. 7257-7263.

Whiley, L.ORCID: 0000-0002-9088-4799, Godzien, J., Ruperez, F.J., Legido-Quigley, C. and Barbas, C. (2012) In-vial dual extraction for direct LC-MS analysis of plasma for comprehensive and highly reproducible metabolic fingerprinting. Analytical Chemistry, 84 (14). pp. 5992-5999.

Whiley, L.ORCID: 0000-0002-9088-4799 and Legido-Quigley, C. (2011) Current strategies in the discovery of small-molecule biomarkers for Alzheimer’s disease. Bioanalysis, 3 (10). pp. 1121-1142.

Heaton, J., Whiley, L.ORCID: 0000-0002-9088-4799, Hong, Y., Mary Sebastian, C., William Smith, N. and Legido-Quigley, C. (2011) Evaluation of Chinese medicinal herbs fingerprinting by HPLC-DAD for the detection of toxic aristolochic acids. Journal of Separation Science, 34 (10). pp. 1111-1115.