Publications: Whiley, Luke

Journal Article

Whiley, L.ORCID: 0000-0002-9088-4799, Chappell, K.E., D’Hondt, E., Lewis, M.R., Jiménez, B., Snowden, S.G., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Swann, J.R., Hye, A., Lovestone, S., Legido-Quigley, C. and Holmes, E. (2021) Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease. Alzheimer's Research & Therapy, 13 (1). Art. 20.

Kimhofer, T., Lodge, S., Whiley, L.ORCID: 0000-0002-9088-4799, Gray, N., Loo, R.L., Lawler, N.G., Nitschke, P., Bong, S-H, Morrison, D.L., Begum, S., Richards, T., Yeap, B.B., Smith, C., Smith, K.G.C., Holmes, E. and Nicholson, J.K. (2020) Integrative modeling of quantitative plasma lipoprotein, metabolic, and amino acid data reveals a multiorgan pathological signature of SARS-CoV-2 infection. Journal of Proteome Research, 19 (11). pp. 4442-4454.

Loo, R.L., Lodge, S., Kimhofer, T., Bong, S-H, Begum, S., Whiley, L.ORCID: 0000-0002-9088-4799, Gray, N., Lindon, J.C., Nitschke, P., Lawler, N.G., Schäfer, H., Spraul, M., Richards, T., Nicholson, J.K. and Holmes, E. (2020) Quantitative In-Vitro diagnostic NMR spectroscopy for lipoprotein and metabolite measurements in plasma and serum: Recommendations for analytical artifact minimization with special reference to COVID-19/SARS-CoV-2 Samples. Journal of Proteome Research, 19 (11). pp. 4428-4441.

Gray, N., Lawler, N.G., Yang, R.ORCID: 0000-0003-2563-2015, Morillon, A-C, Gay, M.C.L., Bong, S-H, Holmes, E., Nicholson, J.K. and Whiley, L.ORCID: 0000-0002-9088-4799 (2020) A simultaneous exploratory and quantitative amino acid and biogenic amine metabolic profiling platform for rapid disease phenotyping via UPLC-QToF-MS. Talanta, 223 (Pt. 2). Art. 121872.

Whiley, L.ORCID: 0000-0002-9088-4799, Chekmeneva, E., Berry, D.J., Jiménez, B., Yuen, A.H.Y., Salam, A., Hussain, H., Witt, M., Takats, Z., Nicholson, J. and Lewis, M.R. (2019) Systematic isolation and structure elucidation of urinary metabolites optimized for the analytical-scale molecular profiling laboratory. Analytical Chemistry, 91 (14). pp. 8873-8882.

Whiley, L.ORCID: 0000-0002-9088-4799, Nye, L.C., Grant, I., Andreas, N., Chappell, K.E., Sarafian, M.H., Misra, R., Plumb, R.S., Lewis, M.R., Nicholson, J.K., Holmes, E., Swann, J.R. and Wilson, I.D. (2019) Ultrahigh-performance liquid chromatography tandem mass spectrometry with electrospray ionization quantification of tryptophan metabolites and markers of gut health in serum and plasma — Application to clinical and epidemiology cohorts. Analytical Chemistry, 91 (8). pp. 5207-5216.

Domingo-Almenara, X., Montenegro-Burke, J.R., Ivanisevic, J., Thomas, A., Sidibé, J., Teav, T., Guijas, C., Aisporna, A.E., Rinehart, D., Hoang, L., Nordström, A., Gómez-Romero, M., Whiley, L.ORCID: 0000-0002-9088-4799, Lewis, M.R., Nicholson, J.K., Benton, H.P. and Siuzdak, G. (2018) XCMS-MRM and METLIN-MRM: A cloud library and public resource for targeted analysis of small molecules. Nature Methods, 15 (9). pp. 681-684.

Kim, M., Nevado-Holgado, A., Whiley, L.ORCID: 0000-0002-9088-4799, Snowden, S.G., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Thambisetty, M., Dobson, R.J.B., Powell, J.F., Lupton, M.K., Simmons, A., Velayudhan, L., Lovestone, S., Proitsi, P., Legido-Quigley, C., Mielke, M. and Martinez, P. (2017) Association between plasma ceramides and hosphatidylcholines and hippocampal brain volume in late onset Alzheimer's disease. Journal of Alzheimer's Disease, 60 (3). pp. 809-817.

Proitsi, P., Kim, M., Whiley, L.ORCID: 0000-0002-9088-4799, Simmons, A., Sattlecker, M., Velayudhan, L., Lupton, M.K., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Powell, J.F., Dobson, R.J.B. and Legido-Quigley, C. (2016) Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis. Alzheimer's & Dementia, 13 (2). pp. 140-151.

Price, M.E., Docx, C.J., Rice, H., Fairhall, S.J., Poole, S.J.C., Bird, M., Whiley, L.ORCID: 0000-0002-9088-4799, Flint, D.P., Green, A.C., Timperley, C.M. and Tattersall, J.E.H. (2016) Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig. Toxicology Letters, 244 . pp. 154-160.

Proitsi, P., Kim, M., Whiley, L.ORCID: 0000-0002-9088-4799, Pritchard, M., Leung, R., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Sham, P., Lovestone, S., Powell, J.F., Dobson, R.J.B. and Legido-Quigley, C. (2015) Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease. Translational Psychiatry, 5 . e494.

Whiley, L.ORCID: 0000-0002-9088-4799, Sen, A., Heaton, J., Proitsi, P., García-Gómez, D., Leung, R., Smith, N., Thambisetty, M., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Lovestone, S. and Legido-Quigley, C. (2014) Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease. Neurobiology of Aging, 35 (2). pp. 271-278.

Godzien, J., Ciborowski, M., Whiley, L.ORCID: 0000-0002-9088-4799, Legido-Quigley, C., Ruperez, F.J. and Barbas, C. (2013) In-vial dual extraction liquid chromatography coupled to mass spectrometry applied to streptozotocin-treated diabetic rats. Tips and pitfalls of the method. Journal of Chromatography A, 1304 . pp. 52-60.

Sen, A., Wang, Y., Chiu, K., Whiley, L.ORCID: 0000-0002-9088-4799, Cowan, D., Chang, R.C-C and Legido-Quigley, C. (2013) Metabolic phenotype of the healthy rodent model using in-vial extraction of dried serum, urine, and cerebrospinal fluid spots. Analytical Chemistry, 85 (15). pp. 7257-7263.

Whiley, L.ORCID: 0000-0002-9088-4799, Godzien, J., Ruperez, F.J., Legido-Quigley, C. and Barbas, C. (2012) In-vial dual extraction for direct LC-MS analysis of plasma for comprehensive and highly reproducible metabolic fingerprinting. Analytical Chemistry, 84 (14). pp. 5992-5999.

Whiley, L.ORCID: 0000-0002-9088-4799 and Legido-Quigley, C. (2011) Current strategies in the discovery of small-molecule biomarkers for Alzheimer’s disease. Bioanalysis, 3 (10). pp. 1121-1142.

Heaton, J., Whiley, L.ORCID: 0000-0002-9088-4799, Hong, Y., Mary Sebastian, C., William Smith, N. and Legido-Quigley, C. (2011) Evaluation of Chinese medicinal herbs fingerprinting by HPLC-DAD for the detection of toxic aristolochic acids. Journal of Separation Science, 34 (10). pp. 1111-1115.