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Publications: Whiley, Luke
Journal Article
Whiley, L.ORCID: 0000-0002-9088-4799, Chappell, K.E., D’Hondt, E., Lewis, M.R., Jiménez, B., Snowden, S.G., Soininen, H., Kłoszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Swann, J.R., Hye, A., Lovestone, S., Legido-Quigley, C. and Holmes, E.
(2021)
Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s disease.
Alzheimer's Research & Therapy, 13
(1).
Art. 20.
Kimhofer, T., Lodge, S., Whiley, L.ORCID: 0000-0002-9088-4799, Gray, N., Loo, R.L., Lawler, N.G., Nitschke, P., Bong, S-H, Morrison, D.L., Begum, S., Richards, T., Yeap, B.B., Smith, C., Smith, K.G.C., Holmes, E. and Nicholson, J.K.
(2020)
Integrative modeling of quantitative plasma lipoprotein, metabolic, and amino acid data reveals a multiorgan pathological signature of SARS-CoV-2 infection.
Journal of Proteome Research, 19
(11).
pp. 4442-4454.
Loo, R.L., Lodge, S., Kimhofer, T., Bong, S-H, Begum, S., Whiley, L.ORCID: 0000-0002-9088-4799, Gray, N., Lindon, J.C., Nitschke, P., Lawler, N.G., Schäfer, H., Spraul, M., Richards, T., Nicholson, J.K. and Holmes, E.
(2020)
Quantitative In-Vitro diagnostic NMR spectroscopy for lipoprotein and metabolite measurements in plasma and serum: Recommendations for analytical artifact minimization with special reference to COVID-19/SARS-CoV-2 Samples.
Journal of Proteome Research, 19
(11).
pp. 4428-4441.
Gray, N., Lawler, N.G., Yang, R.ORCID: 0000-0003-2563-2015, Morillon, A-C, Gay, M.C.L., Bong, S-H, Holmes, E., Nicholson, J.K. and Whiley, L.
ORCID: 0000-0002-9088-4799
(2020)
A simultaneous exploratory and quantitative amino acid and biogenic amine metabolic profiling platform for rapid disease phenotyping via UPLC-QToF-MS.
Talanta, 223
(Pt. 2).
Art. 121872.
Whiley, L.ORCID: 0000-0002-9088-4799, Chekmeneva, E., Berry, D.J., Jiménez, B., Yuen, A.H.Y., Salam, A., Hussain, H., Witt, M., Takats, Z., Nicholson, J. and Lewis, M.R.
(2019)
Systematic isolation and structure elucidation of urinary metabolites optimized for the analytical-scale molecular profiling laboratory.
Analytical Chemistry, 91
(14).
pp. 8873-8882.
Whiley, L.ORCID: 0000-0002-9088-4799, Nye, L.C., Grant, I., Andreas, N., Chappell, K.E., Sarafian, M.H., Misra, R., Plumb, R.S., Lewis, M.R., Nicholson, J.K., Holmes, E., Swann, J.R. and Wilson, I.D.
(2019)
Ultrahigh-performance liquid chromatography tandem mass spectrometry with electrospray ionization quantification of tryptophan metabolites and markers of gut health in serum and plasma — Application to clinical and epidemiology cohorts.
Analytical Chemistry, 91
(8).
pp. 5207-5216.
Domingo-Almenara, X., Montenegro-Burke, J.R., Ivanisevic, J., Thomas, A., Sidibé, J., Teav, T., Guijas, C., Aisporna, A.E., Rinehart, D., Hoang, L., Nordström, A., Gómez-Romero, M., Whiley, L.ORCID: 0000-0002-9088-4799, Lewis, M.R., Nicholson, J.K., Benton, H.P. and Siuzdak, G.
(2018)
XCMS-MRM and METLIN-MRM: A cloud library and public resource for targeted analysis of small molecules.
Nature Methods, 15
(9).
pp. 681-684.
Kim, M., Nevado-Holgado, A., Whiley, L.ORCID: 0000-0002-9088-4799, Snowden, S.G., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Thambisetty, M., Dobson, R.J.B., Powell, J.F., Lupton, M.K., Simmons, A., Velayudhan, L., Lovestone, S., Proitsi, P., Legido-Quigley, C., Mielke, M. and Martinez, P.
(2017)
Association between plasma ceramides and hosphatidylcholines and hippocampal brain volume in late onset Alzheimer's disease.
Journal of Alzheimer's Disease, 60
(3).
pp. 809-817.
Proitsi, P., Kim, M., Whiley, L.ORCID: 0000-0002-9088-4799, Simmons, A., Sattlecker, M., Velayudhan, L., Lupton, M.K., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Lovestone, S., Powell, J.F., Dobson, R.J.B. and Legido-Quigley, C.
(2016)
Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis.
Alzheimer's & Dementia, 13
(2).
pp. 140-151.
Price, M.E., Docx, C.J., Rice, H., Fairhall, S.J., Poole, S.J.C., Bird, M., Whiley, L.ORCID: 0000-0002-9088-4799, Flint, D.P., Green, A.C., Timperley, C.M. and Tattersall, J.E.H.
(2016)
Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig.
Toxicology Letters, 244
.
pp. 154-160.
Proitsi, P., Kim, M., Whiley, L.ORCID: 0000-0002-9088-4799, Pritchard, M., Leung, R., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Sham, P., Lovestone, S., Powell, J.F., Dobson, R.J.B. and Legido-Quigley, C.
(2015)
Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease.
Translational Psychiatry, 5
.
e494.
Whiley, L.ORCID: 0000-0002-9088-4799, Sen, A., Heaton, J., Proitsi, P., García-Gómez, D., Leung, R., Smith, N., Thambisetty, M., Kloszewska, I., Mecocci, P., Soininen, H., Tsolaki, M., Vellas, B., Lovestone, S. and Legido-Quigley, C.
(2014)
Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease.
Neurobiology of Aging, 35
(2).
pp. 271-278.
Godzien, J., Ciborowski, M., Whiley, L.ORCID: 0000-0002-9088-4799, Legido-Quigley, C., Ruperez, F.J. and Barbas, C.
(2013)
In-vial dual extraction liquid chromatography coupled to mass spectrometry applied to streptozotocin-treated diabetic rats. Tips and pitfalls of the method.
Journal of Chromatography A, 1304
.
pp. 52-60.
Sen, A., Wang, Y., Chiu, K., Whiley, L.ORCID: 0000-0002-9088-4799, Cowan, D., Chang, R.C-C and Legido-Quigley, C.
(2013)
Metabolic phenotype of the healthy rodent model using in-vial extraction of dried serum, urine, and cerebrospinal fluid spots.
Analytical Chemistry, 85
(15).
pp. 7257-7263.
Whiley, L.ORCID: 0000-0002-9088-4799, Godzien, J., Ruperez, F.J., Legido-Quigley, C. and Barbas, C.
(2012)
In-vial dual extraction for direct LC-MS analysis of plasma for comprehensive and highly reproducible metabolic fingerprinting.
Analytical Chemistry, 84
(14).
pp. 5992-5999.
Whiley, L.ORCID: 0000-0002-9088-4799 and Legido-Quigley, C.
(2011)
Current strategies in the discovery of small-molecule biomarkers for Alzheimer’s disease.
Bioanalysis, 3
(10).
pp. 1121-1142.
Heaton, J., Whiley, L.ORCID: 0000-0002-9088-4799, Hong, Y., Mary Sebastian, C., William Smith, N. and Legido-Quigley, C.
(2011)
Evaluation of Chinese medicinal herbs fingerprinting by HPLC-DAD for the detection of toxic aristolochic acids.
Journal of Separation Science, 34
(10).
pp. 1111-1115.