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Publications: Veedu, Rakesh

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Number of items: 85.

Journal Article

Larcher, L.M., Wang, T. and Veedu, R.N. (2019) Development of novel antimiRzymes for targeted inhibition of miR-21 expression in solid cancer cells. Molecules, 24 (13). p. 2489.

Chen, S., Le, B.T., Chakravarthy, M., Kosbar, T.R. and Veedu, R.N. (2019) Systematic evaluation of 2′-Fluoro modified chimeric antisense oligonucleotide-mediated exon skipping in vitro. Scientific Reports, 9 (1). Article number 6078.

Thomas, P.B., Jeffery, P.L., Manuel, G.D., Whiteside, E.J., Maugham, M., Walpole, C., Gunter, J.H., Williams, E.D., Nelson, C.C., Herington, A.C., Luque, R.M., Veedu, R.N., Chopin, L.K. and Seim, I. (2018) Abstract 2452: Dysregulated expression of the human long noncoding RNAGHSROSmay influence prostate cancer progression and resistance to docetaxe. Cancer Research, 78 (13 Supp.). p. 2452.

Le, B.T., Raguraman, P., Kosbar, T.R., Fletcher, S., Wilton, S.D. and Veedu, R.N. (2018) Antisense oligonucleotides targeting angiogenic factors as potential cancer therapeutics. Molecular Therapy - Nucleic Acids, 14 (1). pp. 142-157.

Fletcher, N.L., Houston, Z.H., Simpson, J.D., Veedu, R.N. and Thurecht, K.J. (2018) Designed multifunctional polymeric nanomedicines: long-term biodistribution and tumour accumulation of aptamer-targeted nanomaterials. Chemical Communications, 54 (82). pp. 11538-11541.

Chakravarthy, M., Al Shamaileh, H., Huang, H., Tannenberg, R.K., Chen, S., Worrall, S., Dodd, P.R. and Veedu, R.N. (2018) Development of DNA aptamers targeting low-molecular-weight amyloid-β peptide aggregates in vitro. Chemical Communications, 54 (36). pp. 4593-4596.

Macdonald, J., Henri, J., Roy, K., Hays, E., Bauer, M., Veedu, R., Pouliot, N. and Shigdar, S. (2018) EpCAM Immunotherapy versus Specific Targeted Delivery of Drugs. Cancers, 10 (1). E19.

Veedu, R.N. (2018) Evaluation of exon skipping using novel chemically-modified antisense oligonucleotides. Journal of Gene Medicine, 20 (1).

Bao, L.T., Herdewijn, P., Filichev, V.V., Wilton, S.D., Fletcher, S. and Veedu, R.N. (2018) Exploring novel therapeutic chemistries in exon-skipping for duchenne muscular dystrophy. Journal of Gene Medicine, 20 (1).

Hassanzadeh, L., Chen, S. and Veedu, R. (2018) Radiolabeling of nucleic acid aptamers for highly sensitive disease-specific molecular imaging. Pharmaceuticals, 11 (4). p. 106.

Kokil, G.R., Veedu, R.N., Le, B.T., Ramm, G.A. and Parekh, H.S. (2018) Self-assembling asymmetric peptide-dendrimer micelles – a platform for effective and versatile in vitro nucleic acid delivery. Scientific Reports, 8 (1).

Wang, T., Larcher, L., Ma, L. and Veedu, R. (2018) Systematic screening of commonly used commercial transfection reagents towards efficient transfection of single-stranded oligonucleotides. Molecules, 23 (10). p. 2564.

Wang, T., Chen, C., Larcher, L., Barrero, R.A. and Veedu, R.N. (2018) Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development. Biotechnology Advances, 37 (1). pp. 28-50.

Le, B.T., Hughes, Q., Rakesh, S., Baker, R., Jørgensen, P.T., Wengel, J. and Veedu, R.N. (2018) Unlocked nucleic acid modified primer-based enzymatic polymerization assay: Towards allele-specific genotype detection of human platelet antigens. RSC Advances, 8 (57). pp. 32770-32774.

Al Shamaileh, H. and Veedu, R.N. (2017) Next-Generation Nucleic Acid Aptamers with Two-Base-Modified Nucleotides Have Improved Binding Affinity and Potency. ChemBioChem, 18 (16). pp. 1565-1567.

Le, B.T., Murayama, K., Shabanpoor, F., Asanuma, H. and Veedu, R.N. (2017) Antisense oligonucleotide modified with serinol nucleic acid (SNA) induces exon skipping in mdx myotubes. RSC Advances, 7 (54). pp. 34049-34052.

Hughes, Q., Le, B.T., Gilmore, G., Baker, R. and Veedu, R. (2017) Construction of a bivalent thrombin binding aptamer and its antidote with improved properties. Molecules, 22 (10).

Rahimizadeh, K., Al Shamaileh, H., Fratini, M., Chakravarthy, M., Stephen, M., Shigdar, S. and Veedu, R. (2017) Development of Cell-Specific aptamers: Recent advances and insight into the selection procedures. Molecules, 22 (12). p. 2070.

Aaldering, L.J., Poongavanam, V., Langkjaer, N., Murugan, N.A., Jørgensen, P.T., Wengel, J. and Veedu, R.N. (2017) Development of an Efficient G-Quadruplex-Stabilised Thrombin-Binding Aptamer Containing a Three-Carbon Spacer Molecule. ChemBioChem . Early View.

Poongavanam, V., Namasivayam, V., Vanangamudi, M., Al Shamaileh, H., Veedu, R.N., Kihlberg, J. and Murugan, N.A. (2017) Integrative approaches in HIV-1 non-nucleoside reverse transcriptase inhibitor design. Wiley Interdisciplinary Reviews: Computational Molecular Science, 8 (1). e1328.

Chakravarthy, M., Aung-Htut, M.T., Le, B.T. and Veedu, R.N. (2017) Novel Chemically-modified DNAzyme targeting Integrin alpha-4 RNA transcript as a potential molecule to reduce inflammation in multiple sclerosis. Scientific Reports, 7 (1).

Chakravarthy, M., Chen, S., Dodd, P.R. and Veedu, R.N. (2017) Nucleic acid-based theranostics for tackling Alzheimer's Disease. Theranostics, 7 (16). pp. 3933-3947.

Le, B.T., Hornum, M., Sharma, P.K., Nielsen, P. and Veedu, R.N. (2017) Nucleobase-modified antisense oligonucleotides containing 5-(phenyltriazol)-2′-deoxyuridine nucleotides induce exon-skipping in vitro. RSC Advances, 7 (86). pp. 54542-54545.

Le, B.T., Adams, A.M., Fletcher, S., Wilton, S.D. and Veedu, R.N. (2017) Rational design of short locked Nucleic Acid-Modified 2′- O -Methyl antisense oligonucleotides for efficient exon-skipping in vitro. Molecular Therapy - Nucleic Acids, 9 . pp. 155-161.

Chaudhary, R., Roy, K., Kanwar, R.K., Veedu, R.N., Krishnakumar, S., Cheung, C.H.A., Verma, A.K. and Kanwar, J.R. (2016) E-Cadherin Aptamer-Conjugated delivery of Doxorubicin for targeted inhibition of prostate cancer cells. Australian Journal of Chemistry, 69 (10). pp. 1108-1116.

Le, B.T., Chen, S., Abramov, M., Herdewijn, P. and Veedu, R.N. (2016) Evaluation of anhydrohexitol nucleic acid, cyclohexenyl nucleic acid and d-altritol nucleic acid-modified 2′-O-methyl RNA mixmer antisense oligonucleotides for exon skipping in vitro. Chemical Communications, 52 (92). pp. 13467-13470.

Lipi, F., Chen, S., Chakravarthy, M., Rakesh, S. and Veedu, R.N. (2016) In vitro evolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies. RNA Biology, 13 (12). pp. 1232-1245.

Le, B.T., Filichev, V.V. and Veedu, R.N. (2016) Investigation of twisted intercalating nucleic acid (TINA)-modified antisense oligonucleotides for splice modulation by induced exon-skipping in vitro. RSC Advances, 6 (97). pp. 95169-95172.

Veedu, R.N. (2016) Nucleic Acids. Australian Journal of Chemistry, 69 (10). pp. 1071-1072.

Chen, S., Le, B.T., Rahimizadeh, K., Shaikh, K., Mohal, N. and Veedu, R.N. (2016) Synthesis of a morpholino nucleic acid (MNA)-Uridine phosphoramidite, and exon skipping using MNA/2′-O-Methyl mixmer antisense oligonucleotide. Molecules, 21 (11). p. 1582.

Bao, T.L., Veedu, R.N., Fletcher, S. and Wilton, S.D. (2015) Antisense oligonucleotide development for the treatment of muscular dystrophies. Expert Opinion on Orphan Drugs, 4 (2). pp. 139-152.

Sriramoju, B., Kanwar, R., Veedu, R. and Kanwar, J. (2015) Aptamer-Targeted oligonucleotide theranostics: A smarter approach for brain delivery and the treatment of neurological diseases. Current Topics in Medicinal Chemistry, 15 (12). pp. 1115-1124.

Wentrup, C., Kvaskoff, D. and Veedu, R.N. (2015) Comments on photochromism of 3-(3-pyridyl)sydnone and 4-alkenylsydnones. Journal of Photochemistry and Photobiology A: Chemistry, 298 . pp. 62-63.

Veedu, R. (2015) Editorial (Thematic Issue: Medicinal Chemistry of Aptamers). Current Topics in Medicinal Chemistry, 15 (12). p. 1065.

Roy, K., Kanwar, R.K., Antonio Cheung, C.H., Lee Fleming, C., Veedu, R.N., Krishnakumar, S. and Kanwar, J.R. (2015) Locked nucleic acid modified bi-specific aptamer-targeted nanoparticles carrying survivin antagonist towards effective colon cancer therapy. RSC Advances, 5 (37). pp. 29008-29016.

Kanwar, J.R., Roy, K., Maremanda, N.G., Subramanian, K., Veedu, R.N., Bawa, R. and Kanwar, R.K. (2015) Nucleic acid-based aptamers: Applications, development And clinical trials. Current Medicinal Chemistry, 22 (21). pp. 2539-2557.

Aaldering, L.J., Tayeb, H., Krishnan, S., Fletcher, S., Wilton, S.D. and Veedu, R.N. (2015) Smart functional nucleic acid chimeras: Enabling tissue specific RNA targeting therapy. RNA Biology, 12 (4). pp. 412-425.

Edwards, S.L., Poongavanam, V., Kanwar, J.R., Roy, K., Hillman, K.M., Prasad, N., Leth-Larsen, R., Petersen, M., Marušič, M., Plavec, J., Wengel, J. and Veedu, R.N. (2015) Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition. Chemical Communications, 51 (46). pp. 9499-9502.

Kokil, G.R., Veedu, R.N., Ramm, G.A., Prins, J.B. and Parekh, H.S. (2015) Type 2 Diabetes mellitus: Limitations of conventional therapies and intervention with nucleic Acid-Based therapeutics. Chemical Reviews, 115 (11). pp. 4719-4743.

Wilton, S.D., Veedu, R.N. and Fletcher, S. (2015) The emperor's new dystrophin: Finding sense in the noise. Trends in Molecular Medicine, 21 (7). pp. 417-426.

Salsbury, F., Poongavanam, V., Madala, P.K., Højland, T. and Veedu, R.N. (2014) Computational investigation of Locked Nucleic Acid (LNA) nucleotides in the active sites of DNA polymerases by molecular docking simulations. PLoS ONE, 9 (7). e102126.

Kim, K.T., Veedu, R.N., Seo, Y.J. and Kim, B.H. (2014) Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences. Chemical Communications, 50 (13). p. 1561.

Veedu, R.N., Kvaskoff, D. and Wentrup, C. (2014) Sydnone Photochemistry: Direct Observation of Earl's Bicyclic Lactone Valence Isomers (Oxadiazabicyclo[2.1.0]pentanones), Formation of Carbodiimides, Reaction Mechanism, and Photochromism. Australian Journal of Chemistry, 67 (3). pp. 457-468.

Coles, D.J., Rolfe, B.E., Boase, N.R.B., Veedu, R.N. and Thurecht, K.J. (2013) Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo. Chemical Communications, 49 (37). pp. 3836-3838.

Marušič, M., Veedu, R.N., Wengel, J. and Plavec, J. (2013) G-rich VEGF aptamer with locked and unlocked nucleic acid modifications exhibits a unique G-quadruplex fold. Nucleic Acids Research, 41 (20). pp. 9524-9536.

Dawar, S., Singh, N., Kanwar, R.K., Kennedy, R.L., Veedu, R.N., Zhou, S-F, Krishnakumar, S., Hazra, S., Sasidharan, S., Duan, W. and Kanwar, J.R. (2013) Multifunctional and multitargeted nanoparticles for drug delivery to overcome barriers of drug resistance in human cancers. Drug Discovery Today, 18 (23-24). pp. 1292-1300.

Tannenberg, R.K., Al Shamaileh, H., Lauridsen, L.H., Kanwar, J.R., Dodd, P.R. and Veedu, R.N. (2013) Nucleic acid aptamers as novel class of therapeutics to mitigate alzheimer’s disease pathology. Current Alzheimer Research, 10 (4). pp. 442-448.

Morihiro, K., Kodama, T., Kentefu, ., Moai, Y., Veedu, R.N. and Obika, S. (2013) Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes. Angewandte Chemie: International Edition, 52 (19). pp. 5074-5078.

Goubet, A., Chardon, A., Kumar, P., Sharma, P.K. and Veedu, R.N. (2013) Synthesis of DNA oligonucleotides containing C5-ethynylbenzenesulfonamide-modified nucleotides (EBNA) by polymerases towards the construction of base functionalized nucleic acids. Bioorganic & Medicinal Chemistry Letters, 23 (3). pp. 761-763.

Gurudevan, S., Kanwar, R., Veedu, R., Sasidharan, S., Kennedy, R., Walder, K., Prasad, N. and Kanwar, J. (2013) Targeted multimodal liposomes for Nano-delivery and imaging: An avenger for drug resistance and cancer. Current Gene Therapy, 13 (5). pp. 322-334.

Doessing, H., Hansen, L., Veedu, R., Wengel, J. and Vester, B. (2012) Amplification and Re-Generation of LNA-Modified Libraries. Molecules, 17 (12). pp. 13087-13097.

Crouzier, L., Dubois, C., Wengel, J. and Veedu, R.N. (2012) Cleavage and protection of locked nucleic acid–modified DNA by restriction endonucleases. Bioorganic & Medicinal Chemistry Letters, 22 (14). pp. 4836-4838.

Antopolsky, M., Crouzier, L., Dubois, C., Edwards, S.L., Lauridsen, L.H., Wengel, J. and Veedu, R.N. (2012) Efficient Reverse Transcription Using Locked Nucleic Acid Nucleotides towards the Evolution of Nuclease Resistant RNA Aptamers. PloS one, 7 (4). e35990.

Johannsen, M.W., Veedu, R.N., Madsen, A.S. and Wengel, J. (2012) Enzymatic polymerisation involving 2′-amino-LNA nucleotides. Bioorganic & Medicinal Chemistry Letters, 22 (10). pp. 3522-3526.

Højland, T., Veedu, R.N., Vester, B. and Wengel, J. (2012) Enzymatic synthesis of DNA strands containing α-L-LNA (α-L-configured locked nucleic acid) thymine nucleotides. Artificial DNA: PNA & XNA, 3 (1). pp. 14-21.

Lauridsen, L.H. and Veedu, R.N. (2012) Nucleic acid aptamers against biotoxins: A new paradigm toward the treatment and diagnostic approach. Nucleic Acid Therapeutics, 22 (6). pp. 371-379.

Bernhardt, P.V., Kvaskoff, D., Veedu, R.N. and Wentrup, C. (2012) Polymorphism in 3-Pyridylsydnone: Preparative and Structural Aspects. Australian Journal of Chemistry, 65 (4). pp. 376-380.

Lauridsen, L.H., Shamaileh, H.A., Edwards, S.L., Taran, E. and Veedu, R.N. (2012) Rapid One-Step Selection Method for Generating Nucleic Acid Aptamers: Development of a DNA Aptamer against α-Bungarotoxin. PloS one, 7 (7). e41702.

Dubois, C., Campbell, M.A., Edwards, S.L., Wengel, J. and Veedu, R.N. (2012) Stepping towards highly flexible aptamers: Enzymatic recognition studies of unlocked nucleic acid nucleotides. Chemical Communications, 48 (44). p. 5503.

Wheeler, M., Chardon, A., Goubet, A., Morihiro, K., Tsan, S.Y., Edwards, S.L., Kodama, T., Obika, S. and Veedu, R.N. (2012) Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases. Chemical Communications, 48 (89). pp. 11020-11022.

Lauridsen, L.H., Rothnagel, J.A. and Veedu, R.N. (2011) Enzymatic Recognition of 2′-Modified Ribonucleoside 5′-Triphosphates: Towards the Evolution of Versatile Aptamers. ChemBioChem, 13 (1). pp. 19-25.

Pasternak, K., Pasternak, A., Gupta, P., Veedu, R.N. and Wengel, J. (2011) Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers. Bioorganic & Medicinal Chemistry, 19 (24). pp. 7407-7415.

Veedu, R.N. and Wengel, J. (2010) Locked nucleic acids: Promising nucleic acid analogs for therapeutic applications. Chemistry & Biodiversity, 7 (3). pp. 536-542.

Veedu, R.N., Vester, B. and Wengel, J. (2010) Polymerase directed incorporation studies of LNA-G nucleoside 5′-triphosphate and primer extension involving all four LNA nucleotides. New Journal of Chemistry, 34 (5). p. 877.

Veedu, R.N., Burri, H.V., Kumar, P., Sharma, P.K., Hrdlicka, P.J., Vester, B. and Wengel, J. (2010) Polymerase-directed synthesis of C5-ethynyl locked nucleic acids. Bioorganic & Medicinal Chemistry Letters, 20 (22). pp. 6565-6568.

Veedu, R.N., Vester, B. and Wengel, J. (2009) Efficient enzymatic synthesis of LNA-modified DNA duplexes using KOD DNA polymerase. Organic & Biomolecular Chemistry, 7 (7). pp. 1404-1409.

Veedu, R.N. and Wengel, J. (2009) Expanding the applications of locked nucleic acids. Indian Journal of Chemistry, 48B (12). pp. 1709-1711.

Veedu, R.N. and Wengel, J. (2009) Locked nucleic acid as a novel class of therapeutic agents. RNA Biology, 6 (3). pp. 321-323.

Veedu, R.N. and Wengel, J. (2009) Locked nucleic acid nucleoside triphosphates and polymerases: On the way towards evolution of LNA aptamers. Molecular BioSystems, 5 (8). p. 787.

Lecoq, D., Chalmers, B.A., Veedu, R.N., Kvaskoff, D., Bernhardt, P.V. and Wentrup, C. (2009) Microwave-Induced molecular rearrangements. Flash Thermolysis in the Gas-Phase and in solution: Synthesis of Quinolones and Naphthyridones. Australian Journal of Chemistry, 62 (12). p. 1631.

Nagahama, K., Veedu, R.N. and Wengel, J. (2009) Nuclease resistant methylphosphonate-DNA/LNA chimeric oligonucleotides. Bioorganic & Medicinal Chemistry Letters, 19 (10). pp. 2707-2709.

Veedu, R.N., Vester, B. and Wengel, J. (2008) Polymerase chain reaction and transcription using locked nucleic acid nucleotide triphosphates. Journal of the American Chemical Society, 130 (26). pp. 8124-8125.

Veedu, R.N., Kokas, O.J., Couturier-Tamburelli, I., Koch, R., Aycard, J-P, Borget, F. and Wentrup, C. (2008) Reaction of Iminopropadienones with Amines-Formation of Zwitterionic Intermediates, Ketenes, and Ketenimines. The Journal of Physical Chemistry A, 112 (40). pp. 9742-9750.

Veedu, R.N., Bernhardt, P.V., Koch, R. and Wentrup, C. (2008) Twisted push–pull ethylenes. Australian Journal of Chemistry, 61 (10). pp. 805-812.

George, L., Veedu, R.N., Sheibani, H., Taherpour, A.A., Flammang, R. and Wentrup, C. (2007) Carboxyketenes from 4-Hydroxy-1,3-oxazin-6-ones and Meldrum's Acid Derivatives. The Journal of Organic Chemistry, 72 (4). pp. 1399-1404.

Veedu, R.N., Vester, B. and Wengel, J. (2007) Enzymatic Incorporation of LNA Nucleotides into DNA Strands. ChemBioChem, 8 (5). pp. 490-492.

Veedu, R.N., Vester, B. and Wengel, J. (2007) In Vitro Incorporation of LNA Nucleotides. Nucleosides, Nucleotides and Nucleic Acids, 26 (8-9). pp. 1207-1210.

Halton, B., Dixon, G.M., Jones, C.S., Parkin, C.T., Veedu, R.N., Bornemann, H. and Wentrup, C. (2005) A Cyclopropabenzenylidenethenone (Propadienone) via a New Route to Alkylidenecycloproparenes. Organic Letters, 7 (5). pp. 949-952.

Koch, R., Bruhn, T., Veedu, R.N. and Wentrup, C. (2004) Iminopropadienones R–NCCCO and carbon suboxide, C3O2. Theoretical and experimental 13C NMR spectra. Journal of Molecular Structure: THEOCHEM, 686 (1-3). pp. 31-36.

Conference Item

Thomas, P., Jeffrey, P., Gahete, M., Whiteside, E., Walpole, C.M., Maugham, M., Gunter, J., Nelson, C., Herington, A., Luque, R., Veedu, R., Chopin, L. and Seim, I. (2017) The lncRNA GHSROS mediates tumour growth and expression of genes associated. In: The Joint Annual Scientific Meetings of the Endocrine Society of Australia and the Society for Reproductive Biology, 27 - 30 August 2018, Adelaide Convention Centre, SA.

Book Chapter

Aaldering, L., Krishnan, S., Fletcher, S., Wilton, S. and Veedu, R. (2016) Aptamers as therapeutic tools in neurological diseases. In: Veedu, R.N., (ed.) Aptamers: Tools for Nanotherapy and Molecular Imaging. Pan Stanford, pp. 151-167.

Veedu, R.N. and Wengel, J. (2012) Therapeutic applications of locked nucleic acid nucleotides. In: Egli, M. and Herdewijn, P., (eds.) Chemistry and Biology of Artificial Nucleic Acids. Wiley-VCH, Weinheim, Germany, pp. 159-165.

Veedu, R.N. and Wengel, J. (2011) Locked nucleic acid oligonucleotides toward clinical applications. In: Zhang, L-H, Zhen, X. and Chattopadhyaya, J., (eds.) Medicinal Chemistry of Nucleic Acids. John Wiley & Sons Inc., Hoboken, New Jersey, pp. 335-348.

Book

Veedu, R.N. (2016) Aptamers: Tools for Nanotherapy and Molecular Imaging. Pan Stanford.

Others

Wengel, J., Vester, B. and Veedu, R.N. (2009) Enzymatic incorporation of LNA nucleotides. Patent No: WO/2009/039862 .

This list was generated on Sat Jul 20 21:49:18 2019 UTC.