Publications: Trinder, Debbie

Journal Article

Mitchell, T., McKinnon, E., Ayonrinde, O.T., Adams, L.A., Trinder, D., Chua, A., Newton, R., Strakers, L. and Olynyk, J.K. (2018) Decreased physical working capacity in adolescents with Non-Alcoholic fatty liver disease reflects reduced iron bioavailability. Hepatology, 68 . 1317A-1318A.

Chua, A.C.G., Knuiman, M.W., Trinder, D., Divitini, M.L. and Olynyk, J.K. (2016) Higher concentrations of serum iron and transferrin saturation but not serum ferritin are associated with cancer outcomes. American Journal of Clinical Nutrition, 104 (3). pp. 736-742.

Heidari, M., Gerami, S.H., Bassett, B., Graham, R.M., Chua, A.C.G., Aryal, R., House, M.J., Collingwood, J.F., Bettencourt, C., Houlden, H., Ryten, M., Olynyk, J.K., Trinder, D., Johnstone, D.M. and Milward, E.A. (2016) Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases. Rare Diseases, 4 (1). e1198458.

Kalinowski, D.S., Stefani, C., Toyokuni, S., Ganz, T., Anderson, G.J., Subramaniam, N.V., Trinder, D., Olynyk, J.K., Chua, A., Jansson, P.J., Sahni, S., Lane, D.J.R., Merlot, A.M., Kovacevic, Z., Huang, M.L.H., Lee, C.S. and Richardson, D.R. (2016) Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1863 (4). pp. 727-748.

McKinnon, E.J., Rossi, E., Beilby, J.P., Trinder, D. and Olynyk, J.K. (2014) Factors that affect serum levels of ferritin in Australian adults and implications for Follow-up. Clinical Gastroenterology and Hepatology, 12 (1). pp. 101-108.

Chua, A.C.G., Divitini, M.L., Trinder, D., Knuiman, M.W. and Olynyk, J.K. (2014) High iron and transferrin saturation levels are associated with increased risks of non-skin cancers in women. Journal of Gastroenterology and Hepatology, 29 (Supp. 2). p. 147.

Acikyol, B., Graham, R.M., Trinder, D., House, M.J., Olynyk, J.K., Scott, R.J., Milward, E.A. and Johnstone, D.M. (2013) Brain transcriptome perturbations in the transferrin receptor 2 mutant mouse support the case for brain changes in iron loading disorders, including effects relating to long-term depression and long-term potentiation. Neuroscience, 235 . pp. 119-128.

Nakano, H., Chua, A.C.G., Klopcic, B.R.S., Ho, D.S., Fu, S.K., Forrest, C.H., Croft, K.D., Olynyk, J.K., Lawrance, I.C. and Trinder, D. (2013) Dietary iron enhances colonic inflammation and IL-6/IL-11-Stat3 signaling promoting colonic tumor development in mice. PloS one, 8 (11). e78850.

Johnstone, D., Riveros, C., Heidari, M., Graham, R., Trinder, D., Berretta, R., Olynyk, J., Scott, R., Moscato, P. and Milward, E. (2013) Evaluation of different normalization and analysis procedures for illumina gene expression microarray data involving small changes. Microarrays, 2 (2). pp. 131-152.

Hazeldine, S., Trinder, D. and Olynyk, J.K. (2013) Non-Hfe iron overload: Is Phlebotomy the answer? Current Hepatitis Reports, 12 (1). pp. 20-27.

Johnstone, D., Graham, R.M., Trinder, D., Delima, R.D., Riveros, C., Olynyk, J.K., Scott, R.J., Moscato, P. and Milward, E.A. (2012) Brain transcriptome perturbations in the Hfe−/− mouse model of genetic iron loading. Brain Research, 1448 . pp. 144-152.

Johnstone, D.M., Graham, R.M., Trinder, D., Riveros, C., Olynyk, J.K., Scott, R.J., Moscato, P. and Milward, E.A. (2012) Changes in brain transcripts related to alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased alzheimer's disease risk. Journal of Alzheimer's disease : JAD, 30 (4). pp. 791-803.

Delima, R.D., Chua, A.C.G., Tirnitz-Parker, J.E.E., Gan, E.K., Croft, K.D., Graham, R.M., Olynyk, J.K. and Trinder, D. (2012) Disruption of hemochromatosis protein and transferrin receptor 2 causes iron-induced liver injury in mice. Hepatology, 56 (2). pp. 585-593.

Chua, A.C.G., Klopcic, B., Ho, D., Olynyk, J.K., Lawrance, I.C. and Trinder, D. (2011) Colonic interleukin-6 expression is induced by intestinal inflammation and dietary iron. Journal of Gastroenterology and Hepatology, 26 (Supp. 4). p. 17.

Chua, A.C.G., Trinder, D. and Olynyk, J.K. (2011) Liver and serum iron: Discrete regulators of hepatic hepcidin expression. Hepatology, 54 (1). pp. 16-19.

Trinder, D., Delima, R.D., Chua, A.C.G., Ho, D., Graham, R.M. and Olynyk, J.K. (2011) Liver non-transferrin bound iron uptake in vivo is iron regulated in hereditary haemochromatosis. Journal of Gastroenterology and Hepatology, 26 (Supp. 4). p. 7.

Graham, R.M., Chua, A.C.G., Carter, K.W., Delima, R.D., Johnstone, D., Herbison, C.E., Firth, M.J., O'Leary, R., Milward, E.A., Olynyk, J.K. and Trinder, D. (2010) Hepatic iron loading in mice increases cholesterol biosynthesis. Hepatology, 52 (2). pp. 462-471.

Chua, A.C.G., Delima, R.D., Morgan, E.H., Herbison, C.E., Tirnitz-Parker, J.E.E., Graham, R.M., Fleming, R.E., Britton, R.S., Bacon, B.R., Olynyk, J.K. and Trinder, D. (2010) Iron uptake from plasma transferrin by a transferrin receptor 2 mutant mouse model of haemochromatosis. Journal of Hepatology, 52 (3). pp. 425-431.

Chua, A.C.G., Klopcic, B., Lawrance, I.C., Olynyk, J.K. and Trinder, D. (2010) Iron: An emerging factor in colorectal carcinogenesis. World Journal of Gastroenterology, 16 (6). pp. 663-672.

Ferrari, P., Mallon, D., Trinder, D. and Olynyk, J.K. (2010) Pentoxifylline improves haemoglobin and interleukin-6 levels in chronic kidney disease. Nephrology, 15 (3). pp. 344-349.

Gan, E.K., Ayonrinde, O.T., Trinder, D. and Olynyk, J.K. (2010) Phenotypic expression of hereditary hemochromatosis: What have we learned from the population studies? Current Gastroenterology Reports, 12 (1). pp. 7-12.

Gay, M.C.L., Mullaney, I., Trinder, D., Olynyk, J.K. and Trengove, R.D. (2010) Quantitative assay of urinary hepcidin using MALDI-TOF mass spectrometry. Analytical Methods, 2 (3). pp. 268-274.

Herbison, C.E., Thorstensen, K., Chua, A.C.G., Graham, R.M., Leedman, P., Olynyk, J.K. and Trinder, D. (2009) The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells. American Journal of Physiology: Cell Physiology, 297 (6). C1567-C1575.

Ayonrinde, O.T., Milward, E.A., Chua, A.C.G., Trinder, D. and Olynyk, J.K. (2008) Clinical perspectives on hereditary hemochromatosis. Critical Reviews in Clinical Laboratory Sciences, 45 (5). pp. 451-484.

Trinder, D., Ayonrinde, O.T. and Olynyk, J.K. (2008) HCV, iron, and oxidative stress: The new choreography of hepcidin. Gastroenterology, 134 (1). pp. 348-351.

Olynyk, J.K., Trinder, D., Ramm, G.A., Britton, R.S. and Bacon, B.R. (2008) Hereditary hemochromatosis in the post-HFE era. Hepatology, 48 (3). pp. 991-1001.

Graham, R.M., Reutens, G.M., Herbison, C.E., Delima, R.D., Chua, A.C.G., Olynyk, J.K. and Trinder, D. (2008) Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron. Journal of Hepatology, 48 (2). pp. 327-334.

Chua, A.C.G., Herbison, C.E., Drake, S.F., Graham, R.M., Olynyk, J.K. and Trinder, D. (2008) The role of Hfe in transferrin-bound iron uptake by hepatocytes. Hepatology, 47 (5). pp. 1737-1744.

Graham, R.M., Chua, A.C.G., Herbison, C.E., Olynyk, J.K. and Trinder, D. (2007) Liver iron transport. World Journal of Gastroenterology, 13 (35). pp. 4725-4736.

Delima, R., Trinder, D. and Olynyk, J.K. (2007) Potential protective effects of zinc in iron overload. Liver International, 27 (1). pp. 4-5.

Chua, A.C.G., Graham, R.M., Trinder, D. and Olynyk, J.K. (2007) The regulation of cellular iron metabolism. Critical Reviews in Clinical Laboratory Sciences, 44 (5-6). pp. 413-459.

Drake, S.F., Morgan, E.H., Herbison, C.E., Delima, R., Graham, R.M., Chua, A.C.G., Leedman, P.J., Fleming, R.E., Bacon, B.R., Olynyk, J.K. and Trinder, D. (2006) Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3. AJP: Gastrointestinal and Liver Physiology, 292 (1). G323-G328.

Chua, A.C.G., Drake, S.F., Herbison, C.E., Olynyk, J.K., Leedman, P.J. and Trinder, D. (2006) Limited iron export by hepatocytes contributes to hepatic iron-loading in the Hfe knockout mouse. Journal of Hepatology, 44 (1). pp. 176-182.

Siah, C.W., Ombiga, J., Adams, L.A., Trinder, D. and Olynyk, J.K. (2006) Normal iron metabolism and the pathophysiology of iron overload disorders. Clinical Biochemist Reviews, 27 (1). pp. 5-16.

Milward, E., Johnstone, D., Trinder, D., Ramm, G. and Olynyk, J. (2006) The nexus of iron and inflammation in hepcidin regulation: SMADs, STATs, and ECSIT. Hepatology, 45 (1). pp. 253-256.

Olynyk, J.K., Trinder, D. and Milward, E. (2005) Hereditary haemochromatosis: To screen or not to screen? Journal of Hepatology, 43 (1). pp. 9-10.

Siah, C.W., Trinder, D. and Olynyk, J.K. (2005) Iron overload. Clinica Chimica Acta, 358 (1-2). pp. 24-36.

Milward, E.A., Trinder, D., Wilcox, C.E.J., Britton, R.S., Ramm, G.A. and Olynyk, J.K. (2005) Is HFE involved in increased hepcidin expression and hypoferremia in inflammation and anemia of chronic disease? Hepatology, 41 (4). pp. 936-938.

Ombiga, J., Adams, L.A., Tang, K., Trinder, D. and Olynyk, J.K. (2005) Screening for HFE and iron overload. Seminars in Liver Disease, 25 (4). pp. 402-410.

Chua, A.C.G., Olynyk, J.K., Leedman, P.J. and Trinder, D. (2004) Nontransferrin-bound iron uptake by hepatocytes is increased in the Hfe knockout mouse model of hereditary hemochromatosis. Blood, 104 (5). pp. 1519-1525.

Trinder, D., Olynyk, J.K., Sly, W.S. and Morgan, E.H. (2002) Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Proceedings of the National Academy of Sciences, 99 (8). pp. 5622-5626.

Trinder, D., Fox, C., Vautier, G. and Olynyk, J.K. (2002) Molecular pathogenesis of iron overload. Gut, 51 (2). pp. 290-295.

Trinder, D., Macey, D.J. and Olynyk, J.K. (2000) The new iron age. International Journal of Molecular Medicine, 6 (6). pp. 607-619.

Conference Item

Graham, R., Delima, R.D., Johnstone, D., Milward, E.A., Olynyk, J.K. and Trinder, D. (2013) Changes in gene expression of cholesterol metabolism pathways in mouse models of haemochromatosis. In: BioIron 2013, 14 - 18 April 2013, University College, London.

Allan, J., Qui, S., Clark, H., Hofmann, K., Watson, M.ORCID: 0000-0002-6438-9225 and Trinder, D. (2013) Does HCV alter the iron status of infected cells? In: 20th International Symposium on Hepatitis C Virus and Related Viruses, 6-10 October 2013, Melbourne, Australia.

Chua, A., Ho, D.S., Klopcic, B., Olynyk, J., Lawrance, I.C. and Trinder, D. (2012) Liver iron homeostasis is altered by colonic inflammation and dietary iron. In: Australian Gastroenterology Week 2012, 16 - 19 October 2012, Adelaide Convention Centre, S.A.

Mullaney, I., Gay, M.C.L., Maker, G.ORCID: 0000-0003-1666-9377, Trinder, D., Olynyk, J.K. and Trengove, R.D. (2011) Quantitative analysis of hepcidin in biofluids and its role in diagnosis and monitoring of haemochromatosis and anaemia. In: MSACL 2011, 5 - 9 February, San Diego, Ca, USA.

Gay, M.C.L., Trinder, D., Olynyk, J.K., Mullaney, I. and Trengove, R. (2009) Quantitation of hepcidin in body fluids for diagnosis and monitoring of iron disorders. In: 57th ASMS Conference on Mass Spectrometry and Allied Topics, 31 May - 4 June 2009, Philadelphia, USA.

Book Chapter

Milward, E., Acikyol, B., Bassett, B., Williams, E., Graham, R., Delima, R., Trinder, D., Olynyk, J. and Johnstone, D. (2012) Brain changes in iron loading disorders. In: Linert, W. and Kozlowski, H., (eds.) Metal Ions in Neurological Systems. Springer Vienna, pp. 17-29.