Publications: Kemp, Matthew

2022

Takahashi, T., Takahashi, Y., Fee, E.L., Saito, M., Yaegashi, N., Usuda, H., Bridges, J.P., Milad, M.A., Furfaro, L., Carter, S., Schmidt, A.F., Newnham, J.P., Jobe, A.H. and Kemp, M.W. (2022) Continuous but not pulsed low-dose fetal betamethasone exposures extend the durability of antenatal steroid therapy. American Journal of Physiology-Lung Cellular and Molecular Physiology, 322 (6). L784-L793.

Usuda, H., Fee, E.L., Carter, S., Furfaro, L., Takahashi, T., Takahashi, Y., Newnham, J.P., Milad, M.A., Saito, M., Jobe, A.H. and Kemp, M.W. (2022) Low-dose antenatal betamethasone treatment achieves preterm lung maturation equivalent to that of the WHO dexamethasone regimen but with reduced endocrine disruption in a sheep model of pregnancy. American Journal of Obstetrics and Gynecology . In Press.

Fee, E.L., Takahashi, T., Takahashi, Y., Carter, S., Furfaro, L., Clarke, M.W., Milad, M.A., Usuda, H., Newnham, J.P., Saito, M., Jobe, A.H. and Kemp, M.W. (2022) One percent of the clinical dose used for antenatal steroid therapy is sufficient to induce lung maturation when administered directly to the preterm ovine fetus. American Journal of Physiology-Lung Cellular and Molecular Physiology, 322 (6). L853-L865.

Usuda, H., Carter, S., Takahashi, T., Newnham, J.P., Fee, E.L., Jobe, A.H. and Kemp, M.W. (2022) Perinatal care for the extremely preterm infant. Seminars in Fetal and Neonatal Medicine, 27 (2). Art. 101334.

Takahashi, T., Takahashi, Y., Fee, E.L., Usuda, H., Furfaro, L., Newnham, J.P., Jobe, A.H. and Kemp, M.W. (2022) Single nucleotide polymorphisms in surfactant protein A1 are not associated with a lack of responsiveness to antenatal steroid therapy in a pregnant sheep model. Physiological Reports, 10 (19). Art. e15477.

Takahashi, T., Jobe, A.H., Fee, E.L., Newnham, J.P., Schmidt, A.F., Usuda, H. and Kemp, M.W. (2022) The complex challenge of antenatal steroid therapy nonresponsiveness. American Journal of Obstetrics and Gynecology .

2021

Usuda, H., Saito, M., Ikeda, H., Sato, S., Kumagai, Y., Saito, Y., Kawamura, S., Hanita, T., Sakai, H., Kure, S., Yaegashi, N., Newnham, J.P., Kemp, M.W. and Watanabe, S. (2021) Assessment of synthetic red cell therapy for extremely preterm ovine fetuses maintained on an artificial placenta life‐support platform. Artificial Organs . Early View.

Takahashi, T., Fee, E.L., Takahashi, Y., Saito, M., Yaegashi, N., Usuda, H., Furfaro, L., Carter, S., Schmidt, A.F., Newnham, J.P., Jobe, A.H. and Kemp, M.W. (2021) Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birth weights when administered to pregnant sheep in combination with betamethasone acetate. American Journal of Obstetrics and Gynecology, 226 (4). P564.E1-P564.E14.

Heymans, C., den Dulk, M., Lenaerts, K., Heij, L.R., de Lange, I.H., Hadfoune, M., van Heugten, C., Kramer, B.W., Jobe, A.H., Saito, M., Kemp, M.W., Wolfs, T.G.A.M. and van Gemert, W.G. (2021) Chorioamnionitis induces hepatic inflammation and time-dependent changes of the enterohepatic circulation in the ovine fetus. Scientific Reports, 11 (1). Art. 10331.

Takahashi, Y., Saito, M., Usuda, H., Takahashi, T., Watanabe, S., Hanita, T., Sato, S., Kumagai, Y., Koshinami, S., Ikeda, H., Carter, S., Fee, E.L., Furfaro, L., Chemtob, S., Keelan, J., Olson, D., Yaegashi, N., Newnham, J.P., Jobe, A.H. and Kemp, M.W. (2021) Direct administration of the non-competitive interleukin-1 receptor antagonist rytvela transiently reduced intrauterine inflammation in an extremely preterm sheep model of chorioamnionitis. PLoS ONE, 16 (9). Art. e0257847.

Usuda, H., Fee, E.L., Takahashi, T., Takahashi, Y., Carter, S., Newnham, J.P. and Kemp, M.W. (2021) The artificial placenta: SCI-FI or reality? Revista Médica Clínica Las Condes, 32 (6). pp. 699-706.

2020

Kumagai, Y., Usuda, H., Sato, S., Hanita, T., Carter, S., Fee, E.L., Musk, G.C., Yaegashi, N., Jobe, A.H., Newnham, J.P., Kemp, M.W. and Saito, M. (2020) Alterations in fetal ovine cardiac function and gene expression following antenatal steroid exposure. In: 67th Annual Meeting. Society-for-Reproductive-Investigation (SRI) 2020, 10 - 14 March 2020, Vancouver Convention Centre East, BC, Canada.

Jobe, A.H., Kemp, M., Schmidt, A., Takahashi, T., Newnham, J. and Milad, M. (2020) Antenatal corticosteroids: A reappraisal of the drug formulation and dose. Pediatric Research, 89 . pp. 318-325.

Heymans, C., de Lange, I.H., Lenaerts, K., Kessels, L.C.G.A., Hadfoune, M., Rademakers, G., Melotte, V., Boesmans, W., Kramer, B.W., Jobe, A.H., Saito, M., Kemp, M.W., van Gemert, W.G. and Wolfs, T.G.A.M. (2020) Chorioamnionitis induces enteric nervous system injury: Effects of timing and inflammation in the ovine fetus. Molecular Medicine, 26 (1). Art. 82.

Heymans, C., de Lange, I.H., Hütten, M.C., Lenaerts, K., de Ruijter, N.J.E., Kessels, L.C.G.A., Rademakers, G., Melotte, V., Boesmans, W., Saito, M., Usuda, H., Stock, S.J., Spiller, O.B., Payne, M.S., Kramer, B.W., Newnham, J.P., Jobe, A.H., Kemp, M.W., van Gemert, W.G. and Wolfs, T.G.A.M. (2020) Chronic Intra-uterine ureaplasma parvum infection induces injury of the enteric nervous system in ovine fetuses. Frontiers in Immunology, 11 . Art. 189.

Heymans, C., de Lange, I. H., Hütten, M.C., Lenaerts, K., de Ruijter, N.J.E., Kessels, L.C.G.A., Rademakers, G., Melotte, V., Boesmans, W., Saito, M., Usuda, H., Stock, S.J., Spiller, O.B., Beeton, M.L., Payne, M.S., Kramer, B.W., Newnham, J.P., Jobe, A.H., Kemp, M.W., van Gemert, W.G. and Wolfs, T.G.A.M. (2020) Corrigendum: Chronic Intra-Uterine Ureaplasma parvum infection induces injury of the enteric Nervous System in Ovine Fetuses. Frontiers in Immunology, 11 .

Musk, G.C., Usuda, H., Kershaw, H., Kemp, M.W. and Sharp, C.R.ORCID: 0000-0002-1797-9783 (2020) Maternal-fetal blood major crossmatching in Merino Sheep. Comparative Medicine, 70 (4). pp. 355-358.

Heymans, C., Heij, L.R., Lenaerts, K., den Dulk, M., Hadfoune, M., van Heugten, C., Spiller, O.B., Beeton, M.L., Stock, S.J., Jobe, A.H., Payne, M.S., Kemp, M.W., Kramer, B.W., Plat, J., van Gemert, W.G. and Wolfs, T.G.A.M. (2020) Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine Ureaplasma parvum Infection Partly Prevents Liver Inflammation without Interfering with the Enterohepatic Circulation of the Fetal Sheep. Nutrients, 12 (5). Art. 1312.

Usuda, H., Watanabe, S., Saito, M., Ikeda, H., Koshinami, S., Sato, S., Musk, G.C., Fee, E., Carter, S., Kumagai, Y., Takahashi, T., Takahashi, Y., Kawamura, S., Hanita, T., Kure, S., Yaegashi, N., Newnham, J.P. and Kemp, M.W. (2020) Successful use of an artificial placenta-based life support system to treat extremely preterm ovine fetuses compromised by intrauterine inflammation. American Journal of Obstetrics and Gynecology, 223 (5). 755.e1-755.e20.

Takahashi, T., Saito, M., Schmidt, A.F., Usuda, H., Takahashi, Y., Watanabe, S., Hanita, T., Sato, S., Kumagai, Y., Koshinami, S., Ikeda, H., Carter, S., Clarke, M., Fee, E.L., Yaegashi, N., Newnham, J.P., Jobe, A.H. and Kemp, M.W. (2020) Variability in the efficacy of a standardized antenatal steroid treatment is not due to maternal or fetal plasma drug levels. Evidence from a sheep model of pregnancy. American Journal of Obstetrics and Gynecology, 223 (6). 921.e1-921.e10.

2019

Kemp, M.W., Schmidt, A.F. and Jobe, A.H. (2019) Optimizing antenatal corticosteroid therapy. Seminars in Fetal and Neonatal Medicine, 24 (3). pp. 176-181.

Schmidt, A.F., Jobe, A.H., Kannan, P.S., Bridges, J.P., Newnham, J.P., Saito, M., Usuda, H., Kumagai, Y., Fee, E.L., Clarke, M. and Kemp, M.W. (2019) Oral antenatal corticosteroids evaluated in fetal sheep. Pediatric Research, 86 .

Usuda, H., Saito, M., Watanabe, S. and Kemp, M.W. (2019) Response (Letter to the Editors), The Artificial Placenta: Miles to Go Before I Sleep…. American Journal of Obstetrics and Gynecology, 221 (4). pp. 369-370.

Usuda, H., Watanabe, S., Saito, M., Sato, S., Musk, G.C., Fee, E., Carter, S., Kumagai, Y., Takahashi, T., Kawamura, S., Hanita, T., Kure, S., Yaegashi, N., Newnham, J.P. and Kemp, M.W. (2019) Successful use of an artificial placenta to support extremely preterm ovine fetuses at the border of viability. American Journal of Obstetrics and Gynecology, 221 (1).

Kemp, M.W., Saito, M., Schmidt, A.F., Usuda, H., Watanabe, S., Sato, S., Hanita, T., Kumagai, Y., Takahashi, T., Musk, G.C., Furfaro, L., Stinson, L., Fee, E.L., Eddershaw, P.J., Payne, M.S., Smallwood, K., Bridges, J., Newnham, J.P. and Jobe, A.H. (2019) The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation. American Journal of Obstetrics and Gynecology . In Press.

2018

Musk, G.C., Adams, M.J.ORCID: 0000-0002-7743-4515, Usuda, H., Kemp, M.W. and Sharp, C.R.ORCID: 0000-0002-1797-9783 (2018) Crossmatching maternal and fetal blood in sheep. Comparative Medicine, 68 (4). pp. 294-297.

Musk, G.C., McDonnell, N.J., Newman, M. and Kemp, M.W. (2018) Neurologic complications associated with transdermal placement of intrathecal catheters in sheep. Comparative Medicine, 68 (3). pp. 221-226.

Kumagai, Y., Saito, M., Usuda, H., Watanabe, S., Sato, S., Hanita, T., Musk, G.C., Jobe, A.H., Newnham, J.P., Kemp, M.W. and Yaegashi, N. (2018) Post-Surgical Maintenance of Cardiac Function in an Ex Vivo Premature Lamb Model. Reproductive Sciences, 25 (Supp. 1). 212A.

2017

Loughran, C.M., Kemp, M.W. and Musk, G.C. (2017) Maternal and fetal arterial blood gas data in normotensive, singleton, isoflurane anesthetized sheep at 124-126 days of gestation. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 81 (3). pp. 231-234.

2016

Musk, G.C. and Kemp, M.W. (2016) Maternal and fetal arterial blood gas data during general anaesthesia for caesarean delivery of preterm twin lambs. Laboratory Animals, 50 (3). pp. 198-203.

2015

Miura, Y., Saito, M., Usuda, H., Woodward, E., Rittenschober-Böhm, J., Kannan, P.S., Musk, G.C., Matsuda, T., Newnham, J.P. and Kemp, M.W. (2015) Ex-Vivo Uterine Environment (EVE) Therapy Induced Limited Fetal Inflammation in a Premature Lamb Model. PLoS ONE, 10 (10). e0140701.

2014

Gisslen, T., Hillman, N.H., Musk, G.C., Kemp, M.W., Kramer, B.W., Senthamaraikannan, P., Newnham, J.P., Jobe, A.H. and Kallapur, S.G. (2014) Repeated exposure to intra-amniotic LPS partially protects against adverse effects of intravenous LPS in preterm lambs. Innate Immunity, 20 (2). pp. 214-224.

Musk, G.C., Murdoch, F.R., Tuke, J., Kemp, M.W., Dixon, M.J and Taylor, P.M (2014) Thermal and mechanical nociceptive threshold testing in pregnant sheep. Veterinary Anaesthesia and Analgesia, 41 (3). pp. 305-311.

2013

Kemp, M.W., Musk, G.C. and Saito, M. (2013) Animal models for the study of infection-associated preterm birth. In: Conn, M., (ed.) Animal Models for the Study of Human Disease. Academic Press Inc, London, UK, pp. 863-888.

2011

Keelan, J.A., Nitsos, I., Saito, M., Musk, G.C., Kemp, M.W., Timmins, M., Li, S., Yaegashi, N. and Newnham, J.P. (2011) Maternal-amniotic-fetal distribution of macrolide antibiotics following intravenous, intramuscular, and intraamniotic administration in late pregnant sheep. American Journal of Obstetrics and Gynecology, 204 (6). 546.e10-546.e17.