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Publications: Centre for Molecular Medicine and Innovative Therapeutics (CMMIT)

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Number of items at this level: 63.

Journal Article

Ankit, ., Wang, T., Veedu, R.N., Abdmouleh, F., Arbi, M.E. and Kumar, S. (2020) Synthesis and biological evaluation of triazolylnucleosides as antibacterial and anticancer agents. Chemical Data Collections, 28 . Art.100429.

Aung-Htut, M.T., Ham, K.A.ORCID: 0000-0002-7036-5334, Tchan, M., Johnsen, R., Schnell, F.J., Fletcher, S. and Wilton, S.D. (2020) Splice modulating antisense oligonucleotides restore some acid-alpha-glucosidase activity in cells derived from patients with late-onset Pompe disease. Scientific Reports, 10 . Article number: 6702.

Aung-Htut, M.T., Ham, K.A.ORCID: 0000-0002-7036-5334, Tchan, M.C., Fletcher, S. and Wilton, S.D. (2020) Novel mutations found in individuals with adult-onset Pompe disease. Genes, 11 (2). Article 135.

Aung-Htut, M.T., McIntosh, C.S., Ham, K.A.ORCID: 0000-0002-7036-5334, Pitout, I.L., Flynn, L.L., Greer, K., Fletcher, S. and Wilton, S.D. (2019) Systematic approach to developing splice modulating antisense oligonucleotides. International Journal of Molecular Sciences, 20 (20). Article 5030.

Aung-Htut, M.T., McIntosh, C.S., West, K.A.ORCID: 0000-0002-7036-5334, Fletcher, S. and Wilton, S.D. (2019) In vitro validation of phosphorodiamidate morpholino oligomers. Molecules, 24 (16). Article 2922.

Balachandran, A.A., Larcher, L.M., Chen, S. and Veedu, R.N. (2020) Therapeutically significant MicroRNAs in primary and metastatic brain malignancies. Cancers, 12 (9). Article 2534.

Benzian-Olsson, N., Dand, N., Chaloner, C., Bata-Csorgo, Z., Borroni, R., Burden, A.D., Cooper, H.L., Cornelius, V., Cro, S., Dasandi, T., Griffiths, C.E.M., Kingo, K., Kõks, S., Lachmann, H., McAteer, H., Meynell, F., Mrowietz, U., Parslew, R., Patel, P., Pink, A.E., Reynolds, N.J., Tanew, A., Torz, K., Trattner, H., Wahie, S., Warren, R.B., Wright, A., Barker, J.N., Navarini, A.A., Smith, C.H. and Capon, F. (2020) Association of clinical and demographic factors with the severity of Palmoplantar Pustulosis. JAMA Dermatology (Online First). Art. e203275.

Brini, S., Sohrabi, H.R.ORCID: 0000-0001-8017-8682, Hebert, J.J., Forrest, M.R.L., Laine, M., Hämäläinen, H., Karrasch, M., Peiffer, J.J.ORCID: 0000-0002-3331-1177, Martins, R.N. and Fairchild, T.J.ORCID: 0000-0002-3975-2213 (2020) Bilingualism is associated with a delayed onset of dementia but not with a lower risk of developing it: A systematic review with meta-analyses. Neuropsychology Review, 30 . pp. 1-24.

Chakravarthy, M., Chen, S., Wang, T. and Veedu, R.N. (2020) Development of novel chemically-modified nucleic acid molecules for efficient inhibition of human MAPT gene expression. Genes, 11 (6). Article 667.

Chakravarthy, M. and Veedu, R.N. (2019) BACE1 inhibition using 2’-OMePS steric blocking antisense oligonucleotides. Genes, 10 (9).

Chen, J., Wang, J., Deng, Y., Wang, T., Miao, T., Li, C., Cai, X., Liu, Y., Henri, J. and Chen, L. (2020) Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway. Bioinorganic Chemistry and Applications, 2020 . pp. 1-16.

Chen, S., Le, B.T., Chakravarthy, M., Kosbar, T.R. and Veedu, R.N. (2020) Author Correction: Systematic evaluation of 2′-Fluoro modified chimeric antisense oligonucleotide-mediated exon skipping in vitro. Scientific Reports, 10 (1). Art. 6669.

Chen, S., Le, B.T., Chakravarthy, M., Kosbar, T.R. and Veedu, R.N. (2019) Systematic evaluation of 2′-Fluoro modified chimeric antisense oligonucleotide-mediated exon skipping in vitro. Scientific Reports, 9 (1). Article number 6078.

Chen, S., Sbuh, N. and Veedu, R.N. (2020) Antisense oligonucleotides as potential therapeutics for Type 2 Diabetes. Nucleic Acid Therapeutics . Ahead of Print.

Eltermaa, M., Jakobson, M., Utt, M., Kõks, S., Mägi, R. and Starkopf, J. (2019) Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease. BMC Research Notes, 12 (1).

Foster, A.D., Downing, P., Figredo, E., Polain, N., Stott, A., Layfield, R. and Rea, S.L. (2020) ALS-associated TBK1 variant p.G175S is defective in phosphorylation of p62 and impacts TBK1-mediated signalling and TDP-43 autophagic degradation. Molecular and Cellular Neuroscience, 108 . Art. 103539.

Gorecki, A.M., Preskey, L., Bakeberg, M.C., Kenna, J.E., Gildenhuys, C., MacDougall, G., Dunlop, S.A., Mastaglia, F.L., Akkari, P.A., Koengten, F. and Anderton, R.S. (2019) Altered gut microbiome in Parkinson’s disease and the influence of lipopolysaccharide in a human α-Synuclein over-expressing mouse model. Frontiers in Neuroscience, 13 . Article number 839.

Greer, K., Johnsen, R., Nevo, Y., Fellig, T., Fletcher, S. and Wilton, S.D. (2020) Single exon skipping can address a multi-exon duplication in the dystrophin gene. International Journal of Molecular Sciences, 21 (12). Article 4511.

Ham, K.A.ORCID: 0000-0002-7036-5334, Aung-Htut, M.T., Fletcher, S. and Wilton, S.D. (2020) Nonsequential splicing events alter antisense-mediated exon skipping outcome in COL7A1. International Journal of Molecular Sciences, 21 (20). Article 7705.

Huang, D., Thompson, J.A., Charng, J., Chelva, E., McLenachan, S., Chen, S‐C, Zhang, D., McLaren, T.L., Lamey, T.M., Constable, I.J., De Roach, J.N., Aung‐Htut, M.T., Adams, A.M., Fletcher, S., Wilton, S.D. and Chen, F.K. (2020) Phenotype–genotype correlations in a pseudodominant Stargardt disease pedigree due to a novel ABCA4 deletion–insertion variant causing a splicing defect. Molecular Genetics & Genomic Medicine . Art. e1259.

Keegan, N.P. (2020) Pseudoexons of the DMD Gene. Journal of Neuromuscular Diseases, 7 (2). pp. 77-95.

Keegan, N.P., Wilton, S.D. and Fletcher, S. (2019) Breakpoint junction features of seven DMD deletion mutations. Human Genome Variation, 6 (1).

Krishnan, S., Shrestha, Y., Jayatunga, D.P.W., Rea, S., Martins, R. and Bharadwaj, P. (2020) Activate or inhibit? Implications of autophagy modulation as a therapeutic strategy for Alzheimer’s disease. International Journal of Molecular Sciences, 21 (18). Article 6739.

Kõks, G., Pfaff, A.L., Bubb, V.J., Quinn, J.P. and Kõks, S. (2020) At the dawn of the transcriptomic medicine. Experimental Biology and Medicine .

Kõks, G., Prans, E., Ho, X.D., Duy, B.H., Tran, H.D.T., Ngo, N.B.T., Hoang, L.N.N., Tran, H.MT, Bubb, V.J., Quinn, J.P. and Kõks, S. (2020) Genetic interaction between two VNTRs in the MAOA gene is associated with the nicotine dependence. Experimental Biology and Medicine . Art. 153537022091688.

Kõks, S., Ho, X.D., Maasalu, K., Wood, D. and Martson, A. (2019) Analysis of alternative spicing in the transcriptome of osteosarcoma. Asia-Pacific Journal of Clinical Oncology, 15 (S9). pp. 56-102.

Kõks, S., Williams, R.W., Quinn, J., Farzaneh, F., Conran, N., Tsai, S-J, Awandare, G. and Goodman, S.R. (2020) COVID-19: Time for precision epidemiology. Experimental Biology and Medicine . Online First.

Kõks, S., Wood, D.J., Reimann, E., Awiszus, F., Lohmann, C.H., Bertrand, J., Prans, E., Maasalu, K. and Märtson, A. (2019) The genetic variations associated with time to aseptic loosening after total joint arthroplasty. The Journal of Arthroplasty, 35 (4). pp. 981-988.

Larcher, L.M., Wang, T. and Veedu, R.N. (2019) Development of novel antimiRzymes for targeted inhibition of miR-21 expression in solid cancer cells. Molecules, 24 (13). p. 2489.

Le, B.T., Kosbar, T.R. and Veedu, R.N. (2020) Novel disulfide-bridged bioresponsive antisense oligonucleotide induces efficient splice modulation in muscle Myotubes in Vitro. ACS Omega, 5 (29). pp. 18035-18039.

Li, D., Adams, A.M., Johnsen, R.D., Fletcher, S. and Wilton, S.D. (2020) Morpholino oligomer-induced dystrophin isoforms to map the functional domains in the dystrophin protein. Molecular Therapy - Nucleic Acids, 22 . pp. 263-272.

Li, D., Aung-Htut, M.T., Ham, K.A.ORCID: 0000-0002-7036-5334, Fletcher, S. and Wilton, S.D. (2020) A splice intervention therapy for autosomal recessive juvenile Parkinson’s disease arising from Parkin mutations. International Journal of Molecular Sciences, 21 (19). Article 7282.

Li, D., Mastaglia, F.L., Fletcher, S. and Wilton, S.D. (2020) Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era. Medicinal Research Reviews . Early View.

Li, Y., Chen, S., Liu, N., Ma, L., Wang, T., Veedu, R.N., Liu, T., Zhang, F., Zhou, H., Cheng, X. and Jing, X. (2020) A systematic investigation of key factors of nucleic acid precipitation toward optimized DNA/RNA isolation. BioTechniques, 68 (4). pp. 191-199.

Mahoney, S., Bradley, A., Pitts, L., Waletzko, S., Robinson-Lane, S.G., Fairchild, T.ORCID: 0000-0002-3975-2213, Terbizan, D.J. and McGrath, R. (2020) Health insurance is associated with decreased odds for undiagnosed prediabetes and type 2 diabetes in American adults. International Journal of Environmental Research and Public Health, 17 (13). Article 4706.

Marck, C.H., Learmonth, Y.C.ORCID: 0000-0002-4857-8480, Chen, J. and van der Mei, I. (2020) Physical activity, sitting time and exercise types, and associations with symptoms in Australian people with multiple sclerosis. Disability and Rehabilitation . Latest Article.

Martinovich, K., Kicic, A., Fletcher, S., Wilton, S., Stick, S. and Arest, C.F. (2020) Restoring CFTR using antisense oligonucleotides for a cystic fibrosis causing splice mutation C.2989-1G>A. Respirology, 25 (S1). p. 150.

Martinovich, K.M., Kicic, A., Fletcher, S., Wilton, S.D. and Stick, S.M. (2019) Antisense oligonucleotides to improve CFTR function for people with the INTRON 9 5T polymorphism. Pediatric Pulmonology, 54 (S2). S217-S218.

McIntosh, C.S., Aung-Htut, M.T., Fletcher, S. and Wilton, S.D. (2019) Removal of the polyglutamine repeat of ataxin-3 by redirecting pre-mRNA processing. International Journal of Molecular Sciences, 20 (21). Article 5434.

Mejzini, R., Flynn, L.L., Pitout, I.L., Fletcher, S., Wilton, S.D. and Akkari, P.A. (2019) ALS genetics, mechanisms, and therapeutics: Where are we now? Frontiers in Neuroscience, 13 .

Muldmaa, M., Mencacci, N.E., Pittman, A., Kadastik‐Eerme, L., Sikk, K., Taba, P., Hardy, J. and Kõks, S. (2020) Community‐based genetic study of Parkinson's disease in Estonia. Acta Neurologica Scandinavica . Early View.

Naveed, A., Cooper, J.A., Li, R., Hubbard, A., Chen, J., Liu, T., Wilton, S.D., Fletcher, S. and Fox, A.H. (2020) NEAT1 polyA-modulating antisense oligonucleotides reveal opposing functions for both long non-coding RNA isoforms in neuroblastoma. Cellular and Molecular Life Sciences .

Pfaff, A.L., Bubb, V.J., Quinn, J.P. and Kõks, S. (2020) An increased burden of highly active retrotransposition competent L1s is associated with Parkinson’s Disease risk and progression in the PPMI Cohort. International Journal of Molecular Sciences, 21 (18). Art. 6562.

Pitout, I., Flynn, L.L., Wilton, S.D. and Fletcher, S. (2019) Antisense-mediated splice intervention to treat human disease: the odyssey continues. F1000Research, 8 .

Pytte, J., Anderton, R.S., Flynn, L.L., Theunissen, F., Jiang, L., Pitout, I., James, I., Mastaglia, F.L., Saunders, A.M., Bedlack, R., Siddique, T., Siddique, N. and Akkari, P.A. (2020) Association of a structural variant within the SQSTM1 gene with amyotrophic lateral sclerosis. Neurology Genetics, 6 (2). Art. e406.

Pytte, J., Flynn, L.L., Anderton, R.S., Mastaglia, F.L., Theunissen, F., James, I., Pfaff, A., Kõks, S., Saunders, A.M., Bedlack, R., Burns, D.K., Lutz, M.W., Siddique, N., Siddique, T., Roses, A.D. and Akkari, P.A. (2020) Disease-modifying effects of an SCAF4 structural variant in a predominantly SOD1 ALS cohort. Neurology Genetics, 6 (4). e470.

Raguraman, P., Wang, T., Ma, L., Jørgensen, P.T., Wengel, J. and Veedu, R.N. (2020) Alpha-l-Locked nucleic acid-modified antisense oligonucleotides induce efficient splice modulation in vitro. International Journal of Molecular Sciences, 21 (7). Article 2434.

Rea, S.L. and Foster, A.D. (2020) The role of sequestosome 1/p62 protein in amyotrophic lateral sclerosis and frontotemporal dementia pathogenesis. Neural Regeneration Research, 15 (12). pp. 2186-2194.

Roshandel, D., Thompson, J.A., Charng, J., Zhang, D., Chelva, E., Arunachalam, S., Attia, M.S., Lamey, T.M., McLaren, T.L., De Roach, J.N., Mackey, D.A., Wilton, S.D., Fletcher, S., McLenachan, S. and Chen, F.K. (2020) Exploring microperimetry and autofluorescence endpoints for monitoring disease progression in PRPF31-associated retinopathy. Ophthalmic Genetics . pp. 1-14.

Rothzerg, E., Ho, X.D., Xu, J., Wood, D., Märtson, A., Maasalu, K. and Kõks, S. (2020) Alternative splicing of leptin receptor overlapping transcript in osteosarcoma. Experimental Biology and Medicine .

Shaw, N., Kicic, A., Schneider-Daum, N., Fletcher, S., Wilton, S., Huwer, H., Lehr, C., Stick, S. and Schultz, A. (2020) Characterisation of a surrogate Type-II alveolar cell culture model for ATP binding cassette subfamily a member 3 (ABCA-3) deficiency. Respirology, 25 (S1). p. 130.

Theunissen, F., Flynn, L.L., Anderton, R.S., Mastaglia, F., Pytte, J., Jiang, L., Hodgetts, S., Burns, D.K., Saunders, A., Fletcher, S., Wilton, S.D. and Akkari, P.A. (2020) Structural variants may be a source of missing heritability in sALS. Frontiers in Neuroscience, 14 .

Thomas, P.B., Jeffery, P.L., Manuel, G.D., Whiteside, E.J., Maugham, M., Walpole, C., Gunter, J.H., Williams, E.D., Nelson, C.C., Herington, A.C., Luque, R.M., Veedu, R.N., Chopin, L.K. and Seim, I. (2018) Abstract 2452: Dysregulated expression of the human long noncoding RNAGHSROSmay influence prostate cancer progression and resistance to docetaxe. Cancer Research, 78 (13 Supp.). p. 2452.

Vetkas, A., Prans, E., Kõks, S., Rätsep, T. and Asser, T. (2020) Aneurysmal subarachnoid haemorrhage: Effect of CRHR1 genotype on fatigue and depression. BMC Neurology, 20 (1). Art. 142.

Vetkas, A., Prans, E., Kõks, S., Rätsep, T. and Asser, T. (2020) Aneurysmal subarachnoid haemorrhage: Effect of CRHR1 genotype on mental health-related quality of life. Scientific Reports, 10 (1).

Vollstedt, E‐J, Kasten, M., Klein, C., Aasly, J., Adler, C., Ahmad‐Annuar, A., Albanese, A., Alcalay, R., Al‐Mubarak, B., Alvarez, V., Andree‐Muñoz, B., Annesi, G., Appel‐Cresswell, S., Arkadir, D., Armasu, S., Barber, T.R., Bardien, S., Barkhuizen, M., Barrett, M.J., BaŞak, A.N., Beach, T., Benitez, B.A., Berg, D., Bhatia, K., Binkofski, F., Blauwendraat, C., Bonifati, V., Borges, V., Bozi, M., Brice, A., Brighina, L., Brockmann, K., Brüggemann, N., Camacho, M., Cardoso, F., Belin, A.C., Carr, J., Chan, P., Chang‐Castello, J., Chase, B., Chen‐Plotkin, A., Chung, S.J., Cilia, R., Clarimon, J., Clark, L., Cornejo‐Olivas, M., Corvol, J‐C, Cosentino, C., Cras, P., Crosiers, D., Damásio, J., Das, P., Carvalho Aguiar, P., De Michele, G., De Rosa, A., Dieguez, E., Dorszewska, J., Erer, S., Ertan, S., Farrer, M., Fedotova, E., Ferese, R., Ferrarese, C., Ferraz, H., Fiala, O., Foroud, T., Friedman, A., Frigerio, R., Funayama, M., Gambardella, S., Garraux, G., Gatto, E.M., Genç, G., Goldwurm, S., Gomez‐Esteban, J.C., Gómez‐Garre, P., Gorostidi, A., Grosset, D., Hanagasi, H., Hardy, J., Hassan, A., Hattori, N., Hauser, R.A., Hedera, P., Hentati, F., Hertz, J.M., Holton, J.L., Houlden, H., Hutz, M.H., Ikeuchi, T., Illarioshkin, S., Inca‐Martinez, M., Infante, J., Jankovic, J., Jeon, B.S., Jesús, S., Jimenez‐Del‐Rio, M., Kasten, M., Kataoka, H., Kawakami, H., Kim, Y.J., Klein, C., Klivényi, P., Kõks, S., König, I.R., KostiĆ, V., Koziorowski, D., Krüger, R., Krygowska‐Wajs, A., Kulisevsky, J., Lang, A., LeDoux, M., Lesage, S., Lim, S‐Y, Lin, C‐H, Lohmann, K., Lopera, F., Lopez, G., Lu, C‐S, Lynch, T., Machaczka, M., Madoev, H., Magalhães, M., Majamaa, K., Maraganore, D., Marder, K., Markopoulou, K., Martikainen, M.H., Mata, I., Mazzetti, P., Mellick, G., Menéndez‐González, M., Micheli, F., Mirelman, A., Mir, P., Morino, H., Morris, H., Munhoz, R.P., Naito, A., Olszewska, D.A., Ozelius, L.J., Padmanabhan, S., Paisán‐Ruiz, C., Payami, H., Peluso, S., Petkovic, S., Petrucci, S., Pezzoli, G., Pimentel, M., Pirker, W., Pramstaller, P.P., Pulkes, T., Puschmann, A., Quattrone, A., Raggio, V., Ransmayr, G., Rieder, C., Riess, O., Rodriguez‐Porcel, F., Rogaeva, E., Ross, O.A., Ruiz‐Martinez, J., Sammler, E., Luciano, M.S., Satake, W., Saunders‐Pullman, R., Sazci, A., Scherzer, C., Schrag, A., Schumacher‐Schuh, A., Sharma, M., Sidransky, E., Singleton, A.B., Petersen, M.S., Smolders, S., Spitz, M., Stefanis, L., Struhal, W., Sue, C., Swan, M., Swanberg, M., Taba, P., Taipa, R., Tan, M., Tan, A.H., Tan, E‐K, Tang, B., Tayebi, N., Thaler, A., Thomas, A., Toda, T., Toft, M., Torres, L., Tumas, V., Valente, E.M., Van Broeckhoven, C., Vecsei, L., Velez‐Pardo, C., Vidailhet, M., Vollstedt, E‐J, Warner, T.T., Williams‐Gray, C.H., Winkelmann, J., Woitalla, D., Wood, N.W., Wszolek, Z.K., Wu, R‐M, Wu, Y‐R, Xie, T., Yoshino, H., Zhang, B. and Zimprich, A. (2019) Using global team science to identify genetic Parkinson's disease worldwide. Annals of Neurology, 86 (2). pp. 153-157.

Wang, T., Philippovich, S., Mao, J. and Veedu, R.N. (2019) Efficient epidermal growth factor receptor targeting oligonucleotide as a potential molecule for targeted cancer therapy. International Journal of Molecular Sciences, 20 (19).

Wang, T., Rahimizadeh, K. and Veedu, R.N. (2019) Development of a novel DNA oligonucleotide targeting low-density lipoprotein receptor. Molecular Therapy - Nucleic Acids, 19 . pp. 190-198.

Yang, D., Zhang, W., Zhang, H., Zhang, F., Chen, L., Ma, L., Larcher, L.M., Chen, S., Liu, N., Zhao, Q., Tran, P.H.L., Chen, C., Veedu, R.N. and Wang, T. (2020) Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics. Theranostics, 10 (8). pp. 3684-3707.

Zamani Esteki, M., Viltrop, T., Tšuiko, O., Tiirats, A., Koel, M., Nõukas, M., Žilina, O., Teearu, K., Marjonen, H., Kahila, H., Meekels, J., Söderström-Anttila, V., Suikkari, A-M, Tiitinen, A., Mägi, R., Kõks, S., Kaminen-Ahola, N., Kurg, A., Voet, T., Vermeesch, J.R. and Salumets, A. (2019) In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages. Nature Medicine, 25 (11). pp. 1699-1705.

Zaw, K., Greer, K., Aung-Htut, M.T., Mitrpant, C., Veedu, R.N., Fletcher, S. and Wilton, S.D. (2019) Consequences of making the inactive active through changes in antisense oligonucleotide chemistries. Frontiers in Genetics, 10 .

Book Chapter

González-Navarro, H., Dogan, S., Tuna, B.G., Potter, P.K., Kõks, G. and Kõks, S. (2019) Aging in rodents. In: Rattan, S.I.S., (ed.) Reference Module in Biomedical Sciences. Academic Press, pp. 73-87.


McIntosh, Craig Stewart (2020) Antisense oligonucleotide-mediated therapeutic strategies for neurodegenerative repeat expansion diseases. PhD thesis, Murdoch University.

This list was generated on Fri Oct 30 21:32:07 2020 UTC.