Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Differences in heath-related quality of life (HRQL) measured by the PROQOL-HIV, a new specific instrument developed across cultures

Duracinsky, M., Acquadro, C., Lalanne, C., Herrmann, S., Lau, J., Lecoeur, S., Schechter, M., Berzins, B., Fournier-Nicolle, I., Diouf, A. and Chassany, O. (2009) Differences in heath-related quality of life (HRQL) measured by the PROQOL-HIV, a new specific instrument developed across cultures. In: 5th IAS conference on HIV Pathogenesis Treatment and Prevention, 19 - 22 July, Cape Town, South Africa.


Background: The PROQOL-HIV questionnaire, a new instrument measuring the health-related quality-of-life (HRQL) of PLWHA in different cultures, was developed to face the challenges of the HAART era. This study presents the biopsychosocial and clinical factors impacting on HRQL in 8 populations identified by PROQOL-HIV.

Methods: 830 individuals from Australia, Brazil, Cambodia, China, France, Senegal, Thailand and the USA completed the cross-sectional PROQOL-HIV survey. Statistical analyses of HRQL scores were obtained using PROQOL-HIV and correlated with socio-demographic and clinical data, including self reported symptoms.

Results: Mean age was 41±10 years, (37% women, 86% treated). CD4 mean number was 428±268 cells/µL, 75% had undetectable viral load. Total HRQL scores (N=822) were expressed on a 100-point scale, and were similar across most populations. However HIV infection had a greater impact on the HRQL of Chinese and Khmer [with lower HRQL scores (p< .001)], particularly on physical health and symptoms, health concerns, and stigma dimensions (adjusted for multiple comparisons p< .001).Most frequently reported symptoms were tiredness (53%), insomnia (44%), and headache (44%). HRQL scores were inversely correlated with the frequency of self-reported symptoms (p< .001) and varied according to gender (p=0.01): women had mean HRQL scores (60.5±17.5 points) lower than men (63.7±18.1). Individuals with hepatitis co-infection, a psychiatric disorder or an HIV-related disease had lower HRQL scores across all populations (all p< .001) The CD4 count and having an undetectable viral load were also associated with improved HRQL (p< .001): 57.3±18.1(< 250 CD4) vs. 63.5±17.5(>500 CD4) and p< .001, 95%CI [2.7-8.4] respectively, and differed according to the CDC stage (p< .001): 60.2±18.4 (stage C) vs. 63.7±17.7 (non-C stage). Self-reported adherence was high and not associated with HRQL, confirming that HRQL is an important endpoint to measure.

Conclusions: PROQOL-HIV is a valid questionnaire to assess the quality-of-life of PLWHA and is sensitive to clinical outcome measures and cultural differences.

Item Type: Conference Item
Conference Website:
Item Control Page Item Control Page