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Pancreatic response in healthy dogs fed diets of various fat compositions

James, F.E., Mansfield, C.S., Steiner, J.M., Williams, D.A. and Robertson, I.D.ORCID: 0000-0002-4255-4752 (2009) Pancreatic response in healthy dogs fed diets of various fat compositions. American Journal of Veterinary Research, 70 (5). pp. 614-618.

Link to Published Version: http://dx.doi.org/10.2460/ajvr.70.5.614
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Abstract

Objective - To indirectly assess the pancreatic response in healthy dogs that were fed diets of different fat compositions with or without supplemental pancreatic enzymes and medium-chain triglycerides (MCTs). Animals - 10 healthy adult dogs. Procedures - Dogs were fed 4 diets once in random order at 1-week intervals; food was withheld from the dogs for ≥ 12 hours prior to the feeding of each diet. Diets A and B contained 16% and 5% crude fat, respectively; diet C was composed of diet A with pancreatic enzymes; and diet D was composed of diet B with pancreatic enzymes and MCTs. Serum canine trypsin-like immunoreactivity (cTLI) and canine pancreatic lipase immunoreactivity (cPLI) concentrations were measured before (0 hours) and at 1 to 2 and 6 hours after feeding. Serum gastrin concentration was measured at 0 hours and at 5 to 10 minutes and 1 to 2 hours after feeding. A gastrin assay validation study was performed to confirm accuracy of test results in dogs. Data were analyzed by use of a repeated-measures general ANOVA. Results - Serum cTLI, cPLI, or gastrin concentrations in the dogs did not differ among the different diets fed, among dogs, or over time. When multiple comparisons were analyzed, diet D caused the least amount of measurable pancreatic response, although this difference was not significant. Conclusions and Clinical Relevance - Results did not indicate a significant effect of dietary fat content or addition of supplemental MCT oil or pancreatic enzymes in diets on serum cTLI, cPLI, or gastrin concentrations in healthy dogs.

Item Type: Journal Article
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Publisher: American Veterinary Medical Association
URI: http://researchrepository.murdoch.edu.au/id/eprint/7815
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