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In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection

Desport, M., Tenaya, I.W.M., McLachlan, A., McNab, T.J., Rachmat, J., Hartaningsih, N. and Wilcox, G.E. (2009) In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection. Virology, 393 (2). pp. 221-227.

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Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cells in which the viral capsid protein could be detected. Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3+ T-cells or MAC387+ monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary and Biomedical Sciences
Publisher: Elsevier
Copyright: © 2009 Elsevier Inc.
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