Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Association of TGIFLX/Y mRNA expression with prostate cancer

Ousati Ashtiani, Z., Ayati, M., Modarresi, M.H., Raoofian, R., Sabah Goulian, B., Greene, W.K. and Heidari, M. (2009) Association of TGIFLX/Y mRNA expression with prostate cancer. Medical Oncology, 26 (1). pp. 73-77.

[img]
Preview
PDF - Authors' Version
Download (182kB) | Preview
Link to Published Version: http://dx.doi.org/10.1007/s12032-008-9086-7
*Subscription may be required

Abstract

Prostate cancer is the most common type of solid tumor and a leading cause of cancer-related death of men living in the developed world. In recent years, the molecular mechanisms involved in prostate cancer development and/or progression have been intensely studied and several genes have been identified. TGIFLX/Y (TGIFLX and TGIFLY) are members of the homeobox superfamily of genes whose function(s) is unknown. To investigate TGIFLX/Y mRNA expression in prostate cancer, we studied two different types of clinical samples, namely 60 prostate tumors and 15 cases of benign prostate hyperplasia (BPH), by RT-PCR. Our results revealed that most prostate tumors (73.5%) express at least one of these genes, although different patterns of TGIFLX/Y mRNA expression were observed. In some tumor samples the expression of both genes was detected, while in others no expression of either gene was observed. Notably, there was a significant correlation between expression of both TGIFLX and TGIFLY and a Gleason score of >or=6 (P = 0.038). By contrast, expression of TGIFLX/Y mRNA in BPH samples could not be detected. These results suggest an association of TGIFLX/Y expression with the progression of prostate cancer.

Item Type: Journal Article
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Publisher: Humana Press, Inc.
URI: http://researchrepository.murdoch.edu.au/id/eprint/6817
Item Control Page Item Control Page

Downloads

Downloads per month over past year