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Inflammatory responses following a wheelchair basketball match

Tsakonitis, C., Chatzinikolaou, A., Kambas, A., Avloniti, A., Vantarakis, A., Mavropalias, G.ORCID: 0000-0001-7753-5693, Draganidis, D., Tsoukas, D., Jamurtas, A. and Fatouros, I.G. (2014) Inflammatory responses following a wheelchair basketball match. In: 4th Conference of the Greek Society of Biochemistry and Physiology of Exercise, 24 - 26 October 2014, Trikala, Greece

Abstract

Organized sports have become an integral part of the post-clinical phase among individuals with a spinal cord injury (SCI) (Bhambhani et al., 2002) who may be at increased risk for developing cardiovascular and inflammatory risk (Myers et al., 2007). Oxidative stress is up-regulated in cardiovascular and inflammatory conditions in SCI (Laufs et al., 2005) while tram-sports appear to increase oxidative stress markers (Fatouros et al., 2010). The purpose of this study was to determine the effects of a wheelchair basketball match on the responses of oxidative stress and inflammatory markers of SCI. Methods Ten SCI and ten able-bodied (AB) controls participated in a two-group, repeated measures study. VO2peak and maximal heart rate (HRmax) was initially determined during a graded exercise test to exhaustion. Thereafter, both groups participated in a basketball match according to official regulations. Heart rate was monitored throughout the game while blood lactate concentration was measured at baseline, half-time and immediately after the match. Blood samples were collected prior to the two matches, immediately post-match and at 24, 48 and 72h of recovery. Blood samples were analyzed for leukocyte count, creatine kinase (CK), C-reactive protein (CRP), uric acid, protein carbonyls, TBARS, catalase, total antioxidant capacity (TAC), and blood glutathione peroxidase (GPX), reduced glutathione (GSH), and oxidized glutathione (GSSG). Results The two groups were comparable in all oxidative stress and inflammatory markers at baseline. The match induced marked increases in heart rate and lactate in both groups with AB demonstrating more pronounced responses. Inflammatory (leukocytes, CRP, CK, uric acid) increased in both groups with AB demonstrating a more pronounced response than SCI. Oxidative stress (TBARS, protein carbonyls, GSSG, TAC, catalase and GPX) markers increased for ~24 h and subsided thereafter in AB but they remained unaffected in SCI. GSH declined for 24 h after exercise only in AB. Discussion These results suggest that a basketball match elicits a moderate and relatively brief (~24h) inflammatory response in able-bodied individuals whereas in individuals with spinal cord injury basketball activity represents a less stressful stimulus that induces a very brief and mild muscle damage and a minimal inflammatory response.

Item Type: Conference Paper
URI: http://researchrepository.murdoch.edu.au/id/eprint/66564
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