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Evaluating distribution of foveal avascular zone parameters corrected by lateral magnification and their associations with retinal thickness

Li, Q., Gong, P., Ho, P.H., Kennedy, B.F., Mackey, D.A., Chen, F.K. and Charng, J. (2022) Evaluating distribution of foveal avascular zone parameters corrected by lateral magnification and their associations with retinal thickness. Ophthalmology Science, 2 (2). Art. 100134.

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Free to read: https://doi.org/10.1016/j.xops.2022.100134
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Abstract

Purpose
To examine the distribution of foveal avascular zone (FAZ) parameters, with and without correction for lateral magnification, in a large cohort of healthy young adults.

Design
Cross-sectional, observational cohort study.

Participants
A total of 504 healthy adults, 27 to 30 years of age.

Methods
Participants underwent a comprehensive ophthalmic examination including axial length measurement and OCT angiography (OCTA) imaging of the macula. OCT angiography images of combined superficial and deep retinal vessel plexuses were processed via a custom software to extract foveal avascular zone area (FAZA) and foveal density-300 (FD-300), the vessel density in a 300-μm wide annulus surrounding the FAZ, with and without correction for lateral magnification. Bland–Altman analyses were performed to examine the effect of lateral magnification on FAZA and FD-300, as well as to evaluate the interocular agreement in both parameters. Linear mixed-effects models were used to examine the relationship between retinal thicknesses and OCTA parameters.

Main Outcome Measures
The FAZA and FD-300, corrected for lateral magnification.

Results
The mean (standard deviation [SD]) of laterally corrected FAZA and FD-300 was 0.22 mm2 (0.10 mm2) and 51.9% (3.2%), respectively. Relative to uncorrected data, 55.6% of corrected FAZA showed a relative change > 5%, whereas all FD-300 changes were within 5%. There was good interocular symmetry (mean right eye–left eye difference, 95% limits of agreement [LoA]) in both FAZA (0.006 mm2, -0.05 mm2, to 0.07 mm2) and FD-300 (-0.05%, -5.39%, to 5.30%). There were significant negative associations between central retinal thickness and FAZA (β = -0.0029), as well as between central retinal thickness and FD-300 (β = -0.044), with the relationships driven by inner, not outer, retina.

Conclusions
We reported lateral magnification adjusted normative values for FAZA and FD-300 in a large cohort of young, healthy eyes. Clinicians should strongly consider accounting for lateral magnification when evaluating FAZA. Good interocular agreement in FAZA and FD-300 suggests the contralateral eye can be used as control data.

Item Type: Journal Article
Publisher: Elsevier Inc.
Copyright: © 2022 by the American Academy of Ophthalmology.
URI: http://researchrepository.murdoch.edu.au/id/eprint/66525
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