Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

The effects of home-based exercise therapy for breast cancer-related fatigue induced by radical radiotherapy

Mavropalias, G.ORCID: 0000-0001-7753-5693, Cormie, P., Peddle-McIntyre, C.J., Galvão, D.A., Taaffe, D.R., Schofield, C., Ray, S., Zissiadis, Y. and Newton, R.U. (2022) The effects of home-based exercise therapy for breast cancer-related fatigue induced by radical radiotherapy. Breast Cancer .

Free to read:
*No subscription required



Radiotherapy (RT) can lead to cancer-related fatigue (CRF) and decreased health-related quality of life (HRQoL) in breast cancer patients. The purpose of this trial was to examine the feasibility and efficacy of a home-based resistance and aerobic exercise intervention for reducing CRF and improving HRQoL in breast cancer patients during RT.


Women with breast cancer (N = 106) commencing RT were randomized to 12 weeks of home-based resistance and aerobic exercise (EX) or usual care/control (CON). The primary endpoint was CRF, with secondary endpoints of HRQoL, sleep duration and quality, and physical activity. Measurements were undertaken prior to RT, at completion of RT (~ 6 weeks), at completion of the intervention (12 weeks), and 6 and 12 months after RT completion, while CRF was also measured weekly during RT.


Eighty-nine women completed the study (EX = 43, CON = 46). Over the 12-week intervention, EX completed 1–2 resistance training sessions and accumulated 30–40 min of aerobic exercise weekly. For CRF, EX had a quicker recovery both during and post-RT compared to CON (p < 0.05). Moreover, there was a significant difference in HRQoL between groups at RT completion, with HRQoL unchanged in CON and higher in EX (p < 0.05). There was no change in sleep duration or quality for either group and there were no exercise-related adverse effects.


Home-based resistance and aerobic exercise during RT is safe, feasible, and effective in accelerating CRF recovery and improving HRQoL. Improvements in CRF and HRQoL for these patients can be achieved with smaller exercise dosages than stated in the generic recommendations for breast cancer.

Item Type: Journal Article
Murdoch Affiliation(s): Centre for Healthy Ageing
Centre for Molecular Medicine and Innovative Therapeutics
Publisher: Springer Nature
Copyright: © 2022 The Authors.
Item Control Page Item Control Page


Downloads per month over past year