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Cytoplasmic binding of dexamethasone and induction of tyrosine aminotransferase in neonatal rat liver

Cake, M.H.ORCID: 0000-0002-5899-7291, Ghisalberti, A.V. and Oliver, I.T. (1973) Cytoplasmic binding of dexamethasone and induction of tyrosine aminotransferase in neonatal rat liver. Biochemical and Biophysical Research Communications, 54 (3). pp. 983-990.

Link to Published Version: https://doi.org/10.1016/0006-291X(73)90791-2
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Abstract

Dexamethasone administration markedly increases the activity of tyrosine aminotransferase in postnatal rat liver. The glucocorticoid fails to induce the enzyme in foetal rats when administered in utero. Dexamethasone binding activity of rat liver cytoplasm is low or absent in foetal animals but increases to adult levels 1–2 days after birth. In vitro experiments with isolated nuclei indicate that foetal nuclei have the capacity to accumulate dexamethasone but only when presented with cytosol-bound glucocorticoid.

Item Type: Journal Article
Publisher: Academic Press
Copyright: © 1973 Published by Elsevier Inc.
URI: http://researchrepository.murdoch.edu.au/id/eprint/66433
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