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Associations of the lipidome with ageing, cognitive decline and exercise behaviours

Kadyrov, M., Whiley, L.ORCID: 0000-0002-9088-4799, Brown, B.ORCID: 0000-0001-7927-2540, Erickson, K.I. and Holmes, E. (2022) Associations of the lipidome with ageing, cognitive decline and exercise behaviours. Metabolites, 12 (9). Article 822.

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One of the most recognisable features of ageing is a decline in brain health and cognitive dysfunction, which is associated with perturbations to regular lipid homeostasis. Although ageing is the largest risk factor for several neurodegenerative diseases such as dementia, a loss in cognitive function is commonly observed in adults over the age of 65. Despite the prevalence of normal age-related cognitive decline, there is a lack of effective methods to improve the health of the ageing brain. In light of this, exercise has shown promise for positively influencing neurocognitive health and associated lipid profiles. This review summarises age-related changes in several lipid classes that are found in the brain, including fatty acyls, glycerolipids, phospholipids, sphingolipids and sterols, and explores the consequences of age-associated pathological cognitive decline on these lipid classes. Evidence of the positive effects of exercise on the affected lipid profiles are also discussed to highlight the potential for exercise to be used therapeutically to mitigate age-related changes to lipid metabolism and prevent cognitive decline in later life.

Item Type: Journal Article
Murdoch Affiliation(s): Psychology, Counselling, Exercise Science and Chiropractic
Australian National Phenome Centre
Centre for Computational and Systems Medicine
Centre for Healthy Ageing
Health Futures Institute
Publisher: MDPI
Copyright: © 2022 by the authors
United Nations SDGs: Goal 3: Good Health and Well-Being
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