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Reactivity to heparin in patients with alpha-gal allergy

Koo, G., Plager, J., Fahrenholz, J.M., Phillips, E. and Stone, C. (2022) Reactivity to heparin in patients with alpha-gal allergy. Annals of Allergy, Asthma & Immunology . In Press.

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Galactose-alpha-1,3-galactose (alpha-gal) syndrome is an immunoglobulin (Ig)E-mediated allergy syndrome to an oligosaccharide found in nonprimate mammalian meat and mammalian-derived products. 1 Oral consumption reactions are characteristically delayed, but are immediate with parenteral administration. 1 Since the discovery of alpha-gal IgE antibodies while investigating hypersensitivity reactions to cetuximab, much attention has been paid to both theoretical risks and reported cases of hypersensitivity reactions to various medications and medical devices derived from nonprimate mammals. 1 ,2 The true extent of this risk is still largely unknown. 3 One medication of interest is heparin; both unfractionated heparin and low-molecular weight heparin, enoxaparin, are derived from porcine intestinal tissue. In a case of immediate hypersensitivity to heparin in a patient with a high concentration of alpha-gal–specific IgE (sIgE), we would like to draw attention to positive skin testing result to heparin products.

Item Type: Journal Article
Murdoch Affiliation(s): Institute for Immunology and Infectious Diseases
Publisher: Elsevier Inc.
Copyright: © 2022 American College of Allergy, Asthma & Immunology.
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