Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Non-Modifiable factors as moderators of the relationship between physical activity and brain volume: A Cross-Sectional UK Biobank Study

Brown, B.M.ORCID: 0000-0001-7927-2540, de Frutos Lucas, J., Porter, T., Frost, N., Vacher, M., Peiffer, J.J.ORCID: 0000-0002-3331-1177 and Laws, S.M. (2022) Non-Modifiable factors as moderators of the relationship between physical activity and brain volume: A Cross-Sectional UK Biobank Study. Journal of Alzheimer's disease : JAD, 88 (3). pp. 1091-1101.

Link to Published Version: https://doi.org/10.3233/JAD-220114
*Subscription may be required

Abstract

Background:Previous research suggests physical activity attenuates grey and white matter loss; however, there appears to be individual variability in this effect. Understanding factors that can influence the relationship between physical activity and brain volume may enable prediction of individual response. Objective:The current study examined the relationship between objectively-measured physical activity and brain volume; and whether this relationship is moderated by age, sex, or a priori candidate genetic factors, brain-derived neurotrophic factor (BDNF) Val66Met, or apolipoprotein (APOE) ɛ4 allele carriage. Methods:Data from 10,083 men and women (50 years and over) of the UK Biobank were used to examine the study objectives. All participants underwent a magnetic resonance imaging scan to quantify grey and white matter volumes, physical activity monitoring via actigraphy, and genotyping. Results:Physical activity was associated with total grey matter volume, total white matter volume, and right hippocampal volume. Only males had an association between higher physical activity levels and greater cortical grey matter volume, total grey matter volume, and right hippocampal volume. Age moderated the relationship between physical activity and white matter volume. Conclusion:Our results indicate that in males, but not females, an association exists between objectively-measured physical activity and grey matter volume. Age may also play a role in impacting the relationship between physical activity and brain volume. Future research should evaluate longitudinal brain volumetrics to better understand the nature of age and sex-effects on the physical activity and brain volume relationship.

Item Type: Journal Article
Murdoch Affiliation(s): Centre for Healthy Ageing
Publisher: IOS Press
United Nations SDGs: Goal 3: Good Health and Well-Being
URI: http://researchrepository.murdoch.edu.au/id/eprint/65707
Item Control Page Item Control Page