MicroRNA-126 participates in lipid metabolism in mammary epithelial cells

Chu, M., Zhao, Y., Feng, Y., Zhang, H., Liu, J., Cheng, M., Li, L., Shen, W., Cao, H., Li, Q. and Min, L. (2017) MicroRNA-126 participates in lipid metabolism in mammary epithelial cells. Molecular and Cellular Endocrinology, 454 . pp. 77-86.

Abstract

Lipids are a major component of milk and are important for infant growth and development. MicroRNA-126 (miR-126) has previously been observed in mammary glands and adipocytes and is known to be involved in lipid metabolism during the process of atherosclerosis. However, it remains unknown whether miR-126 also participates in lipid metabolism in mammary luminal epithelial cells (MECs). In the current investigation, miR-126-3p inhibition stimulated lipid synthesis in MECs in part through increasing levels of the lipid synthesis enzymes FASN, ACSL1, and Insig1. Overexpression of miR-126-3p decreased lipid content in MECs with a reduction in FASN and Insig1. Furthermore, the expression of miR-126-3p was diminished by the steroid hormones estradiol and progesterone with a subsequent elevation of lipid formation in MECs. We also noted that miR-126-3p was expressed differentially at various stages of murine mammary gland development, exhibiting a negative correlation with FASN. Together these findings suggest that miR-126-3 might be involved in lipid metabolism in mammary gland.

Item Type:	Journal Article
Publisher:	Elsevier
Copyright:	© 2017 Elsevier B.V.
URI:	http://researchrepository.murdoch.edu.au/id/eprint/65294

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