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Mining functional information from cereal genomes–the utility of expressed sequence tags

Sreenivasulu, N., Kishor, P.B.K., Varshney, R.K.ORCID: 0000-0002-4562-9131 and Altschmied, L. (2002) Mining functional information from cereal genomes–the utility of expressed sequence tags. Current Science, 83 (8). pp. 965-973.

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The vast number of expressed sequence tags (ESTs) generated from cereals with large genome size is an important complement method to the whole genome sequencing projects. As technology-driven revolution sweeps through, we are submerged in an avalanche of new information about genes and their function. To accomplish functional roles to the available ESTs, proper annotation of EST data is crucial, which could be achieved through the employment of tools of bioinformatics generated in the recent past. In this review, the critical steps involved in EST-based gene discovery and the employment of available web-based bioinformatic tools for annotation of ESTs is discussed. The current status of application of EST clones in the development of molecular markers in cereal species and utilizing ESTs as a resource for the construction of arrays is summarized as well. We also focus on large-scale gene expression data analysis methods and the challenges for computational biologists to extract functional information from such large-scale gene expression data.

Item Type: Journal Article
Publisher: Indian Academy of Sciences
Copyright: © 2002 Current Science Association, Bengaluru
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