Wheat Panache: A pangenome graph database representing presence–absence variation across sixteen bread wheat genomes

Bayer, P.E., Petereit, J., Durant, É., Monat, C., Rouard, M., Hu, H., Chapman, B., Li, C., Cheng, S., Batley, J. and Edwards, D. (2022) Wheat Panache: A pangenome graph database representing presence–absence variation across sixteen bread wheat genomes. The Plant Genome . Early View.

Abstract

Bread wheat (Triticum aestivum L.) is one of humanity's most important staple crops, characterized by a large and complex genome with a high level of gene presence–absence variation (PAV) between cultivars, hampering genomic approaches for crop improvement. With the growing global population and the increasing impact of climate change on crop yield, there is an urgent need to apply genomic approaches to accelerate wheat breeding. With recent advances in DNA sequencing technology, a growing number of high-quality reference genomes are becoming available, reflecting the genetic content of a diverse range of cultivars. However, information on the presence or absence of genomic regions has been hard to visualize and interrogate because of the size of these genomes and the lack of suitable bioinformatics tools. To address this limitation, we have produced a wheat pangenome graph maintained within an online database to facilitate interrogation and comparison of wheat cultivar genomes. The database allows users to visualize regions of the pangenome to assess PAV between bread wheat genomes.

Item Type:	Journal Article
Murdoch Affiliation(s):	Western Crop Genetics Alliance
Publisher:	Wiley Periodicals LLC on behalf of Crop Science Society of America
Copyright:	© 2022 The Authors.
United Nations SDGs:	Goal 12: Responsible Consumption and Production
URI:	http://researchrepository.murdoch.edu.au/id/eprint/65069

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