Endothelial biomarkers of thrombosis in critically ill patients with acquired coagulopathy: A prospective cohort study

Harahsheh, Y., Ludewick, H., Pavey, W. and Ho, K.M. (2022) Endothelial biomarkers of thrombosis in critically ill patients with acquired coagulopathy: A prospective cohort study. Biomarkers in Medicine, 16 (9). Art. 0576.

Abstract

Background: It remains largely unknown whether endothelial biomarkers can be used to predict thromboembolism in critically ill patients with an acquired coagulopathy. Materials & methods: The ability of syndecan-1, P-selectin and microRNA expressions to predict thromboembolism were assessed in 40 critically ill coagulopathic patients. Results: The area under the receiver operating characteristic curves for syndecan-1, P-selectin and the four differentially expressed microRNAs – determined by real-time qPCR analysis – to predict thromboembolism (n = 10, 25%) were 0.71 (95% CI 0.52–0.89), 0.73 (95% CI 0.52–0.95) and >0.80, respectively. Syndecan-1 and P-selectin concentrations were also significantly correlated with one another (R = 0.41, p = 0.008). Conclusion: Endothelial function biomarkers, including endothelial microRNA expressions, were associated with subsequent thromboembolism in critically ill patients who had a deranged coagulation profile.

Item Type:	Journal Article
Murdoch Affiliation(s):	School of Veterinary and Life Sciences
Publisher:	Future Medicine Ltd.
Copyright:	© 2022 Future Science Group
URI:	http://researchrepository.murdoch.edu.au/id/eprint/64956

Item Control Page