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Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum

Doré, V., Doecke, J.D., Saad, Z.S., Triana‐Baltzer, G., Slemmon, R., Krishnadas, N., Bourgeat, P., Huang, K., Burnham, S., Fowler, C., Rainey‐Smith, S.R., Bush, A.I., Ward, L., Robertson, J., Martins, R.N., Masters, C.L., Villemagne, V.L., Fripp, J., Kolb, H.C. and Rowe, C.C. (2022) Plasma p217+tau versus NAV4694 amyloid and MK6240 tau PET across the Alzheimer's continuum. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 14 (1). Art. e12307.

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We evaluated a new Simoa plasma assay for phosphorylated tau (P-tau) at aa217 enhanced by additional p-tau sites (p217+tau).


Plasma p217+tau levels were compared to 18F-NAV4694 amyloid beta (Aβ) positron emission tomography (PET) and 18F-MK6240 tau PET in 174 cognitively impaired (CI) and 223 cognitively unimpaired (CU) participants.


Compared to Aβ− CU, the plasma levels of p217+tau increased 2-fold in Aβ+ CU and 3.5-fold in Aβ+ CI. In Aβ− the p217+tau levels did not differ significantly between CU and CI. P217+tau correlated with Aβ centiloids P = .67 (CI, P = .64; CU, P = .45) and tau SUVRMT P = .63 (CI, P = .69; CU, P = .34). Area under curve (AUC) for Alzheimer's disease (AD) dementia versus Aβ− CU was 0.94, for AD dementia versus other dementia was 0.93, for Aβ+ versus Aβ− PET was 0.89, and for tau+ versus tau− PET was 0.89.


Plasma p217+tau levels elevate early in the AD continuum and correlate well with Aβ and tau PET.

Item Type: Journal Article
Publisher: Wiley Periodicals, LLC on behalf of Alzheimer's Association
Copyright: © 2022 The Authors.
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