Single-cell multi-omic approaches define common molecular and cellular signals of dominant antigen-driven cells at the site of drug-induced Stevens Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) tissue damage

Gibson, A., Li, Y., Thorne, M., Ram, R., Palubinsky, A., Choshi, P., Porter, M., Trubiano, J., Deshpande, P., Chopra, A., Leary, S., Gangula, R., White, K., Pilkington, M., Konvinse, K., Wang, C-W, Pan, R-Y, Hung, S-I, Chung, W-H, Peter, J., Mallal, S. and Phillips, E. (2022) Single-cell multi-omic approaches define common molecular and cellular signals of dominant antigen-driven cells at the site of drug-induced Stevens Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) tissue damage. Journal of Allergy and Clinical Immunology, 149 (2). Art. AB181.

Abstract

Human leukocyte antigen (HLA)-restricted CD8+ T-cells expressing dominant T-cell receptor (TCR) clonotypes are recently implicated drivers of keratinocyte cell death, cutaneous blistering, and mortality in drug-induced Stevens Johnson Syndrome/Toxic epidermal necrolysis (SJS/TEN). Signatures of these effector population(s) remain undefined in affected tissue but hold utility for early diagnosis and targeted therapy.

Item Type:	Journal Article
Murdoch Affiliation(s):	Institute for Immunology and Infectious Diseases
Publisher:	Mosby Inc.
Copyright:	© 2021 Published by Elsevier Inc.
URI:	http://researchrepository.murdoch.edu.au/id/eprint/64576

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