Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Alginate oligosaccharides ameliorate busulfan-induced renal tubule injury

Yan, X., Ma, X., Hao, Y., Liu, J., Fang, H., Lu, D., Shen, W., Zhang, H., Ge, W. and Zhao, Y. (2022) Alginate oligosaccharides ameliorate busulfan-induced renal tubule injury. Journal of Functional Foods, 92 . Art. 105048.

PDF - Published Version
Download (6MB) | Preview
Free to read:
*No subscription required


Kidney diseases endanger human health and place a heavy burden on global health care systems. The current study aimed to explore the beneficial advances of alginate oligosaccharides (AOS) as a functional food on kidney structure and function, and the underlying mechanisms with a busulfan disrupted kidney model. We found that AOS improved the busulfan disrupted renal tubules. Busulfan increased the protein levels of kidney injury marker kidney injury molecule-1, apoptosis marker caspase 3 and inflammation marker TNF-α while they were recovered by AOS. On the other hand, AOS promoted the expression of proteins involved in vascular development α-SMA, CD34 and TGF-β which were decreased by busulfan. Furthermore, AOS elevated the beneficial blood metabolites levels while reduced the harmful blood metabolites levels. Therefore, AOS can be applied to improve kidney function for the patients who take chemotherapeutics such as busulfan or other patients with chronic kidney diseases.

Item Type: Journal Article
Murdoch Affiliation(s): College of Science, Health, Engineering and Education
Publisher: Elsevier Ltd.
Copyright: © 2022 The Author(s).
Item Control Page Item Control Page


Downloads per month over past year