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The role of IL-6 in skin fibrosis and cutaneous wound healing

Johnson, B.Z., Stevenson, A.W., Prêle, C.M., Fear, M.W. and Wood, F.M. (2020) The role of IL-6 in skin fibrosis and cutaneous wound healing. Biomedicines, 8 (5). Art. 101.

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The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and reparative process: it is involved in the differentiation, activation, and proliferation of leukocytes, endothelial cells, keratinocytes, and fibroblasts. This review examines the role of IL-6 in the healing of cutaneous wounds, and how dysregulation of IL-6 signaling can lead to either fibrosis or a failure to heal. The role of an IL-6/TGF-β feedback loop is discussed in the context of fibrogenesis, while IL-6 expression and responses in advanced age, diabetes, and obesity is outlined regarding the development of chronic wounds. Current research on therapies that modulate IL-6 is explored. Here, we consider IL-6′s diverse impact on cutaneous wound healing.

Item Type: Journal Article
Publisher: MDPI
Copyright: © 2022 The Authors.
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