The effect of IGF-1 plasma concentration on COVID-19 severity
Hazrati, E., Gholami, M., Farahani, R.H., Ghorban, K., Ghayomzadeh, M. and Rouzbahani, N.H. (2022) The effect of IGF-1 plasma concentration on COVID-19 severity. Microbial Pathogenesis, 164 . Art. 105416.
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Abstract
Background
The severity and fatality of Coronavirus disease 2019 (COVID-19) infection are not the same in the infected population. The host immune response and Immune-stimulating factors appear to play a role in COVID-19 infection outcome. insulin-like growth factor-1 (IGF-1) affects the immune system by controlling the endocrine system. Recently, the effect of IGF-1 levels on COVID-19 prognosis has been considered.
Objective
To investigate the difference between circulating IGF-1 and inflammatory cytokines concentration among COVID-19 patients, infected patients admitted to the Intensive Care Unit (ICU) (n = 40; 35 ± 5 y) and patients with mild cases of COVID-19 (n = 40; 35 ± 5 y) were screened prior to participation in the study. There was no significant difference between the groups in terms of gender and preexisting inflammatory state. Collected samples were evaluated by ELISA for IGF-1 and IL-6.
Results
The study outcomes included a significant decrease in IGF-1 and an increase in IL-6 serum concentration, as an inflammatory marker, for infected patients admitted to the Intensive Care Unit (ICU) (P ≤ 0.001). Finally, there was a significant increase in the IGF-1 and a decrease in the IL-6 serum concentration of hospitalized patients.
Discussion
it appears that inflammatory cytokines (IL-6) serum concentration in the severe form of corona virus-based infections causes reduced defenses because of suppressed IGF-1.
Conclusions
Our findings show that lower IGF-1 concentrations are associated with a Severe form of COVID-19 disease. It seems, IGF-1 supplementation or anti-inflammatory treatment rescued the severe form of COVID-19 infection. Further studies are required to determine how to design COVID-19 therapeutic strategies targeting the IGF-1 pathway.
Item Type: | Journal Article |
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Murdoch Affiliation(s): | Murdoch Applied Sports Science Laboratory |
Publisher: | Elsevier Limited |
Copyright: | © 2022 Elsevier Ltd. |
URI: | http://researchrepository.murdoch.edu.au/id/eprint/63814 |
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