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Innovative approaches for treatment of osteosarcoma

Rothzerg, E., Pfaff, A.L.ORCID: 0000-0002-2231-9800 and Kõks, S. (2022) Innovative approaches for treatment of osteosarcoma. Experimental Biology and Medicine .

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Osteosarcoma (OS) is the most common primary malignant bone tumor, which usually occurs in children and adolescents. It is generally a high-grade malignancy presenting with extreme metastases to the lungs or other bones. The etiology of the disease is multifaceted and still remains obscure. A combination of surgery and chemotherapy has played a major role in the treatment of OS over the past three decades, and consequently, the overall survival rates for the disease have remained unchanged. Therefore, there is an urgent need to employ new comprehensive analyses and technologies to develop significantly more informative classification systems, with the aim of developing more effective and less toxic therapies for OS patients. This review discusses the existing knowledge of OS therapy and potential methods to develop novel therapeutic agents for the disease.

Item Type: Journal Article
Murdoch Affiliation(s): Centre for Molecular Medicine and Innovative Therapeutics (CMMIT)
Publisher: SAGE Publications
Copyright: © 2022 by The Society for Experimental Biology and Medicine
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