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A retrospective multi‐center study of treatment, outcome, and prognostic factors in 34 dogs with disseminated aspergillosis in Australia

Lim, Y.Y., Mansfield, C.S., Stevenson, M., Thompson, M., Davies, D., Whitney, J., James, F., Tebb, A., Fry, D., Buob, S., Hambrook, L., Boo, G. and Dandrieux, J.R.S. (2022) A retrospective multi‐center study of treatment, outcome, and prognostic factors in 34 dogs with disseminated aspergillosis in Australia. Journal of Veterinary Internal Medicine, 36 (2). pp. 580-590.

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Abstract

Background

Disseminated aspergillosis (DA) in dogs has a guarded prognosis and there is a lack of a gold standard treatment protocol.

Objective

To retrospectively assess survival times and factors influencing survival times.

Animals

Dogs diagnosed with DA from January 2007 to June 2017.

Methods

Disseminated aspergillosis case data were retrieved from 13 Australian veterinary referral centers, with a diagnosis confirmed with culture or PCR. Factors influencing survival time after diagnosis were quantified using a Cox proportional hazards regression model.

Results

Thirty-four dogs met the study inclusion criteria. Twenty-two dogs were treated with antifungal treatment and 12 dogs received no antifungal treatment. Accounting for censoring of dogs that were either still alive on the date of data collection or were loss to follow-up, dogs treated with itraconazole alone (n = 8) had a median survival time (MST) of 63 (95% CI: 20−272) days compared to 830 (95% CI: 267-1259) days for the n = 14 dogs that received multimodal antifungal therapy (

Item Type: Journal Article
Murdoch Affiliation(s): Veterinary Medicine
Publisher: American College of Veterinary Internal Medicine
Copyright: © 2022 The Authors.
URI: http://researchrepository.murdoch.edu.au/id/eprint/63764
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