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Posterior reversible encephalopathy syndrome (PRES): Diagnosis and management

Triplett, J.D., Kutlubaev, M.A., Kermode, A.G. and Hardy, T. (2022) Posterior reversible encephalopathy syndrome (PRES): Diagnosis and management. Practical Neurology, 22 (3). pp. 183-189.

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Posterior reversible encephalopathy syndrome (PRES) may present with diverse clinical symptoms including visual disturbance, headache, seizures and impaired consciousness. MRI shows oedema, usually involving the posterior subcortical regions. Triggering factors include hypertension, pre-eclampsia/eclampsia, renal failure, cytotoxic agents and autoimmune conditions. The mechanism underlying PRES is not certain, but endothelial dysfunction is implicated. Treatment is supportive and involves correcting the underlying cause and managing associated complications, such as seizures. Although most patients recover, PRES is not always reversible and may be associated with considerable morbidity and even mortality.

Item Type: Journal Article
Murdoch Affiliation(s): Centre for Molecular Medicine and Innovative Therapeutics
Publisher: BMJ Publishing Group
Copyright: © 2022 Author(s) (or their employer(s))
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