Serum NfL associated with anti-NMDA receptor encephalitis
Ma, X., Lu, Y., Peng, F., Wang, Y., Sun, X., Luo, W., Shen, S., Liu, Z., Kermode, A.G., Qiu, W. and Shu, Y. (2022) Serum NfL associated with anti-NMDA receptor encephalitis. Neurological Sciences .
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Abstract
Introduction
Neurofilament light chains (NfL) have been reported as potential markers for neuronal-axonal injury in neuroinflammatory diseases. In the current study, we describe serum NfL levels as a prognostic marker for anti-N-methyl-D-aspartate receptor encephalitis (NMDARE).
Methods
Serum levels of NfL of 64 patients with anti-NMDARE and 84 healthy controls were measured by Simoa. The anti-NMDAR Encephalitis One-Year Functional Status (NEOS) score, Modified Rankin Scale (mRS) scores, and clinical and cerebrospinal fluid parameters were evaluated in patients with anti-NMDARE. Meanwhile, we performed a receiver-operator characteristic analysis to assess the power of the serum NFL in predicting the 1-year functional status.
Results
Serum NfL levels were significantly elevated in patients with anti-NMDARE compared to healthy controls (p < 0.001, padjusted < 0.001), especially in patients with severe impairments (mRS > 3 vs ≤ 3, p = 0.035) or with limited response to treatment (vs. favorable outcome, p = 0.011). Serum NFL was positively associated with the initial admission mRS (r = 0.23, p = 0.072) and 1-year mRS (r = 0.29, p = 0.018). The AUC of serum NfL and NEOS score for 1-year poor functional status was 0.697 (95% CI 0.527–0.866, p = 0.011), 0.753 (95% CI 0.616–0.890, p = 0.001), respectively. Furthermore, AUC of the combination of serum NfL and NEOS was 0.815 (95% CI 0.680–0.950, p < 0.001).
Conclusion
Our findings show that serum NfL levels evaluated in anti-NMDAR encephalitis may be a good predictor of the risk of 1-year poor functional status.
Item Type: | Journal Article |
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Murdoch Affiliation(s): | Institute for Immunology and Infectious Diseases |
Publisher: | Springer Nature |
URI: | http://researchrepository.murdoch.edu.au/id/eprint/63707 |
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