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Clostridioides difficile infection and One Health: An equine perspective

Hain‐Saunders, N.M.R., Knight, D.R.ORCID: 0000-0002-9480-4733, Bruce, M.ORCID: 0000-0003-3176-2094 and Riley, T.V. (2022) Clostridioides difficile infection and One Health: An equine perspective. Environmental Microbiology . Early View.

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Clostridioides (Clostridium) difficile presents a significant health risk to humans and animals. The complexity of the bacterial–host interaction affecting pathogenesis and disease development creates an ongoing challenge for epidemiological studies, control strategies and prevention planning. The recent emergence of human disease caused by strains of C. difficile found in animals adds to mounting evidence that C. difficile infection (CDI) may be a zoonosis. In equine populations, C. difficile is a known cause of diarrhoea and gastrointestinal inflammation, with considerable mortality and morbidity. This has a significant impact on both the well-being of the animal and, in the case of performance and production animals, it may have an adverse economic impact on relevant industries. While C. difficile is regularly isolated from horses, many questions remain regarding the impact of asymptomatic carriage as well as optimization of diagnosis, testing and treatment. This review provides an overview of our understanding of equine CDI while also identifying knowledge gaps and the need for a holistic One Health approach to a complicated issue.

Item Type: Journal Article
Murdoch Affiliation(s): Centre for Biosecurity and One Health
Harry Butler Institute
Publisher: Society for Applied Microbiology
Copyright: © 2022 The Authors.
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