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Immunoanalytic investigation of grain proteins antigenic for celiac disease patients in an einkorn collection

Birinyi, Z., Réder, D., Diós, Á., Korponay-Szabó, I.R., Hunyadi-Gulyás, É., Florides, C.G., Juhász, A. and Gell, G. (2022) Immunoanalytic investigation of grain proteins antigenic for celiac disease patients in an einkorn collection. Food Chemistry, 371 . Art. 131148.

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Our study focuses on the complex characterization of a wild and cultivated einkorn collection of the Cereal Gene Bank of Agriculture Research Institute in Hungary, using proteomics, immune analytics and bioinformatics analyses. In a serological ELISA pre-screen of 208 different Triticum monococcum L. ssp. monococcum and Triticum monococcum L. ssp. aegilopoides genotypes with celiac disease samples high diversity was observed in the immune response. Based on the immune analytic results, four genotypes with significantly reduced immune reactivity were selected for detailed proteomics characterization. Our results confirm the benefits of high-throughput/large-scale pre-screening and the use of a complex examination platform to get relevant information about the genetic diversity of celiac disease-relevant proteins in the analyzed einkorn genotypes. These genotypes cannot be incorporated into the daily diet of celiac patients; however, they may represent candidates – especially in combination with enzymatic treatments - to improve the lifestyle of individuals suffering from other clinical conditions like non-celiac wheat sensitivity.

Item Type: Journal Article
Murdoch Affiliation(s): College of Science, Health, Engineering and Education
Publisher: Elsevier Limited
Copyright: © 2021 The Author(s).
United Nations SDGs: Goal 3: Good Health and Well-Being
Goal 12: Responsible Consumption and Production
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