Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population

Laenoi, W., Uddin, M.J., Çınar, M.U., Große-Brinkhaus, C., Tesfaye, D., Jonas, E., Scholz, A.M., Tholen, E., Looft, C., Wimmers, K., Phatsara, C., Juengst, H., Sauerwein, H., Mielenz, M. and Schellander, K. (2011) Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population. Genetics Selection Evolution, 43 (1). Art. 13.

PDF - Published Version
Download (440kB) | Preview
Free to read:
*No subscription required



Leg weakness issues are a great concern for the pig breeding industry, especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim of this study was to identify quantitative trait loci (QTL) affecting leg weakness in pigs.


Three hundred and ten F2 pigs from a Duroc × Pietrain resource population were genotyped using 82 genetic markers. Front and rear legs and feet scores were based on the standard scoring system. Osteochondrosis lesions were examined histologically at the head and the condylus medialis of the left femur and humerus. Bone mineral density, bone mineral content and bone mineral area were measured in the whole ulna and radius bones using dual energy X-ray absorptiometry. A line-cross model was applied to determine QTL regions associated with leg weakness using the QTL Express software.


Eleven QTL affecting leg weakness were identified on eight autosomes. All QTL reached the 5% chromosome-wide significance level. Three QTL were associated with osteochondrosis on the humerus end, two with the fore feet score and two with the rear leg score. QTL on SSC2 and SSC3 influencing bone mineral content and bone mineral density, respectively, reached the 5% genome-wide significance level.


Our results confirm previous studies and provide information on new QTL associated with leg weakness in pigs. These results contribute towards a better understanding of the genetic background of leg weakness in pigs.

Item Type: Journal Article
Publisher: BMC part of Springer Nature
Copyright: © 2011 Laenoi et al
Item Control Page Item Control Page


Downloads per month over past year