Murdoch University Research Repository

Welcome to the Murdoch University Research Repository

The Murdoch University Research Repository is an open access digital collection of research
created by Murdoch University staff, researchers and postgraduate students.

Learn more

A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease

Klatt, S., Doecke, J.D., Roberts, A., Boughton, B.A.ORCID: 0000-0001-6342-9814, Masters, C.L., Horne, M. and Roberts, B.R. (2021) A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease. npj Parkinson's Disease, 7 (1). Art. 94.

PDF - Published Version
Download (1MB) | Preview
Free to read:
*No subscription required


Characterisation and diagnosis of idiopathic Parkinson’s disease (iPD) is a current challenge that hampers both clinical assessment and clinical trial development with the potential inclusion of non-PD cases. Here, we used a targeted mass spectrometry approach to quantify 38 metabolites extracted from the serum of 231 individuals. This cohort is currently one of the largest metabolomic studies including iPD patients, drug-naïve iPD, healthy controls and patients with Alzheimer’s disease as a disease-specific control group. We identified six metabolites (3-hydroxykynurenine, aspartate, beta-alanine, homoserine, ornithine (Orn) and tyrosine) that are significantly altered between iPD patients and control participants. A multivariate model to predict iPD from controls had an area under the curve (AUC) of 0.905, with an accuracy of 86.2%. This panel of metabolites may serve as a potential prognostic or diagnostic assay for clinical trial prescreening, or for aiding in diagnosing pathological disease in the clinic.

Item Type: Journal Article
Murdoch Affiliation(s): Australian National Phenome Center
Publisher: Nature Publishing Group
Copyright: © 2021 The Authors.
Item Control Page Item Control Page


Downloads per month over past year