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Antimicrobial resistance in Clostridioides difficile

O’Grady, K., Knight, D.R.ORCID: 0000-0002-9480-4733 and Riley, T.V. (2021) Antimicrobial resistance in Clostridioides difficile. European Journal of Clinical Microbiology & Infectious Diseases .

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Antimicrobial resistance (AMR) in Clostridioides difficile remains a significant threat to global healthcare systems, not just for the treatment of C. difficile infection (CDI), but as a reservoir of AMR genes that could be potentially transferred to other pathogens. The mechanisms of resistance for several antimicrobials such as metronidazole and MLSB-class agents are only beginning to be elucidated, and increasingly, there is evidence that previously unconsidered mechanisms such as plasmid-mediated resistance may play an important role in AMR in this bacterium. In this review, the genetics of AMR in C. difficile will be described, along with a discussion of the factors contributing to the difficulty in clearly determining the true burden of AMR in C. difficile and how it affects the treatment of CDI.

Item Type: Journal Article
Murdoch Affiliation(s): Centre for Biosecurity and One Health
Harry Butler Institute
Publisher: Springer Verlag
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