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Trend towards reduced burden of proven/probable invasive fungal infections in adult non-allo-HSCT neutropenic patients with acute leukemia

Senn, L., Calandra, T., Robinson, J. and Marchetti, O. (2006) Trend towards reduced burden of proven/probable invasive fungal infections in adult non-allo-HSCT neutropenic patients with acute leukemia. In: 14th International Symposium of Infections in the Immunocompromised Host, 2 - 5 July 2006, Crans Montana, Switzerland.

Abstract

Background: In Leukemic patients IFI are associated with severe morbidity and high mortality (30 to 90%). Moreover, IFI may have a negative impact on treatment and outcome of Leukemia. Recent progresses in diagnosis and management of IFI may have improved outcome. Objectives: To evaluate the morbidity and mortaLity of proven/probabLe IFI in adult non-aLLo-HSCT neutropenic patients with acute Leukemia. Methods: CLinicaL, radioLogicaL, and Laboratory data were prospectively coLLected in consecutive neutropenic patients with acute Leukemia (2002-2005). Antifunga[ prophylaxis was not used routinely. IFI were classified as proven, probable, or possible (EORTC-BAMSG). Proven/probabLe IFI cases were compared to controls (no IFI). Results: 157 neutropenic episodes (91 induction chemotherapy, 64 consolidation, 2 auto-HSCT) occurred in 86 patients (73 AML, 13 ALL). Median age was 57yr (range 19-77). IFI was proven/probabLe in 26 cases (14 aspergillosis, 14 candidiasis, including 2 mixed IFI) and possible in 28. Proven/probabLe IFI occurred during induction chemotherapy in 69% of cases. At admission neutropenia was present in 27% of IFI cases. Median days of in-hospitaL neutropenia were 25 (range 16-71) vs. 20 (range 7-59), respectively (p...

Item Type: Conference Item
URI: http://researchrepository.murdoch.edu.au/id/eprint/61713
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