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Vancomycin exposure and acute kidney injury outcome: A Snapshot From the CAMERA2 Study

Liu, J., Tong, S.Y.C., Davis, J.S., Rhodes, N.J., Scheetz, M.H., Anagostou, N., Andresen, D., Archuleta, S., Bak, N., Cass, A., Chatfield, M., Cheng, A., Davies, J., Davis, J., Dishon, Y., Dotel, R., Ferguson, P., Foo, H., Fowler, V., Ghosh, N., Gray, T., Guy, S., Holmes, N., Howden, B., Johnson, S., Kalimuddin, S., Lye, D., McBride, S., McKew, G., Meagher, N., Nelson, J., O’Sullivan, M., Paterson, D., Paul, M., Price, D., Ralph, A., Roberts, M., Robinson, O., Rogers, B., Runnegar, N., Smith, S., Sud, A., Tong, S., Tramontana, A., Van Hal, S., Walls, G., Warner, M., Yahav, D. and Young, B. (2020) Vancomycin exposure and acute kidney injury outcome: A Snapshot From the CAMERA2 Study. Open Forum Infectious Diseases, 7 (12). Art. ofaa538.

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Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin group. Day 2 vancomycin AUC ≥470 mg·h/L was significantly associated with AKI, independent of (flu)cloxacillin receipt.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary and Life Sciences
Publisher: Oxford University Press on behalf of the Infectious Diseases Society of America.
Copyright: © 2020 The Authors.
Other Information: Courtesy of the CAMERA2 Study Group
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