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Robinson, J.O. and Christiansen, K. (2017) Garenoxacin. In: Grayson, M.L., Cosgrove, S.E., Crowe, S.E., Hope, W., McCarthy, J.S., Mills, J., Mouton, J.W. and Paterson, D.L., (eds.) Kucers’ The Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs. CRC Press.

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Garenoxacin is a des-fluoro(6) quinolone that, as such, lacks a fluorine at the C-6 position in comparison with other fluoroquinolones such as ciprofloxacin, moxifloxacin, and levofloxacin, and has a difluoromethoxy substitution at position C-8 (Fung-Tomc et al., 2000). The molecular formula is 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-(1-methyl-2, 3-dihydro-1H-5-isoindolyl)-4-oxo-1, 4-dihydro-3-quinoline-carboxylic acid methanesulfonate monohydrate (Takahata et al., 1999) (see Figure 114.1). Figure 114.1 Chemical structure of garenoxacin.

Item Type: Book Chapter
Publisher: CRC Press
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