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Increasing secondary resistance to fluoroquinolones amongst Helicobacter pylori in Western Australia

Pateria, P., Chin, M., Goodheart, R., McCullough, C., Raby, E., Robinson, J.O. and Ingram, P.R. (2020) Increasing secondary resistance to fluoroquinolones amongst Helicobacter pylori in Western Australia. Tasman Madical Journal, 2 (1). pp. 15-19.

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Abstract

Background: The Australian Therapeutic Guidelines does not endorse culture and susceptibility testing prior to salvage therapy for Helicobacter pylorieradication. We wished to determine whether this remains appropriate.

Aim: To determine the sensitivity (as minimum inhibitory concentrations, MIC) of H pylorito a range of antibiotics used in salvage therapy over time.

Methods: From 2012 to 2017, gastric or duodenal biopsy samples were obtained from 154 patients receiving H pylorieradication therapy. MIC for amoxicillin, clarithromycin, tetracycline, metronidazole, rifampicin and levofloxacinwere measured using standard laboratory techniques.

Results: A significant increase from zero to 28% in secondary resistance to levofloxacin amongst H. pyloriin Western Australia was noted over the study period. No corresponding trend was seen with the other antibiotics.

Conclusions: These findings suggest that selective use of culture and susceptibility testing may be warranted prior to initiating salvage therapy with levofloxacin.

Item Type: Journal Article
Publisher: Tasman Journals
Publisher's Website: https://tasmanmedicaljournal.com/2020/03/increasin...
URI: http://researchrepository.murdoch.edu.au/id/eprint/61642
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