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Reversibility of the effects of GnRH-vaccination used to suppress reproductive function in mares

Schulman, M.L., Botha, A.E., Muenscher, S. B., Annandale, C.H.ORCID: 0000-0002-0525-8954, Guthrie, A.J. and Bertschinger, H.J. (2012) Reversibility of the effects of GnRH-vaccination used to suppress reproductive function in mares. Equine Veterinary Journal, 45 (1). pp. 111-113.

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Reasons for performing study
Active immunisation against gonadotrophin-releasing hormone (GnRH) provides a reversible method for control of oestrous behaviour and fertility in mares. Previous reports failed to demonstrate the interval to resumption of cyclic ovarian activity after GnRH-vaccination.

Administration of the GnRH-vaccine Improvac in a large group of mares of various ages will result in effective, reliably reversible suppression of ovarian activity within a 2 year period.

The mares, subdivided into 3 age categories, were vaccinated twice (with a 35 day interval) using 400 µg Improvac and monitored via blood samples until Day 720 after initial vaccination for serum progesterone concentration determination by radioimmune assay and anti-GnRH antibody titre by enzyme immunoassay. Samples were collected until individuals resumed cyclic ovarian activity.

All mares showed suppression of cyclic ovarian activity by clinical examination and serum progesterone concentration (SPC) ≤ 1 nmol/l by Day 70 and 92.2% resumed cyclic activity by SPC at Day 720 with a mean interval = 417.8 days (s.d. ± 23.9; range 232-488 days, median 344 days). A significant age effect (P = 0.028) on the interval, but not on GnRH-antibody titre response, was observed between the youngest (≤ 4 years) and oldest (≥ 11 years) categories.

Immunising adult mares of all ages with Improvac resulted in a reversible suppression of cyclic ovarian activity in most mares. An age effect, with the youngest mares showing a longer interval to reversibility, was observed.

Item Type: Journal Article
Publisher: Equine Veterinary Journal Ltd.
Copyright: © 2012 EVJ Ltd
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