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SPON1 Is associated with Amyloid-β and APOE ε4-Related cognitive decline in cognitively normal adults

Fernandez, S., Burnham, S.C., Milicic, L., Savage, G., Maruff, P., Peretti, M., Sohrabi, H.R.ORCID: 0000-0001-8017-8682, Lim, Y.Y., Weinborn, M., Ames, D., Masters, C.L., Martins, R.N., Rainey-Smith, S., Rowe, C.C., Salvado, O., Groth, D., Verdile, G., Villemagne, V.L., Porter, T. and Laws, S.M. (2021) SPON1 Is associated with Amyloid-β and APOE ε4-Related cognitive decline in cognitively normal adults. Journal of Alzheimer's Disease Reports, 5 (1). pp. 111-120.

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Abstract

Background:

Genetic variation in Spondin-1, specifically rs11023139, has been associated with reduced rates of cognitive decline in individuals with Alzheimer’s disease.

Objective:

The aim of this study was to assess whether the association was present in cognitively normal older adults.

Methods:

Longitudinal cognitive decline was investigated using linear mixed modelling in a cohort of 590 cognitively normal older adults enrolled in the Australian Imaging, Biomarkers and Lifestyle Study.

Results:

No independent effect of Spondin-1 rs11023139 on cognitive decline was observed. However, significant associations were observed for the interaction between Apolipoprotein E (APOE) ɛ4 and rs11023139 in individuals with high amyloid-β burden. APOE ɛ4/rs11023139-A carriers declined significantly faster than APOE ɛ4/rs11023139-G_G carriers in measures of global cognition (p = 0.011) and verbal episodic memory (p = 0.020).

Conclusion:

These results suggest that carriage of the Spondin-1 rs11023139-A allele significantly contributes to a worsening of cognitive performance in APOE ɛ4 cognitively normal older adults with a high neocortical amyloid-β burden.

Item Type: Journal Article
Murdoch Affiliation(s): Centre for Healthy Ageing
Publisher: IOS Press
Copyright: © 2021 The Authors.
URI: http://researchrepository.murdoch.edu.au/id/eprint/60340
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