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Sigma factor modulation for cyanobacterial metabolic engineering

Srivastava, A., Varshney, R.K.ORCID: 0000-0002-4562-9131 and Shukla, P. (2021) Sigma factor modulation for cyanobacterial metabolic engineering. Trends in Microbiology, 29 (3). pp. 266-277.

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Sigma (σ) factors are key regulatory proteins that control the transcription initiation in prokaryotes. In response to environmental or developmental cues, σ factors initiate the transcription of necessary genes responsible for maintaining a life-sustaining metabolic balance. Due to the significant role of σ factors in bacterial metabolism, their rational engineering for commercial metabolite production in photoautotrophic, cyanobacterial cells is a desirable venture. As cyanobacterial genomes typically encode multiple σ factors, effective execution of metabolic engineering efforts largely relies on uncovering the complicated gene regulatory network and further characterization of the members of σ factor regulatory circuits. This review outlines the prospects of σ factor in metabolic engineering of cyanobacteria, summarizes the challenges in the path towards an efficient strain construction and highlights the genomic context of putative regulators of cyanobacterial σ factors.

Item Type: Journal Article
Publisher: Cell Press
Copyright: © 2020 Elsevier Ltd.
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