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S100/CD34-Positive Spindle Cell Mesenchymal Neoplasm Harboring KIAA1549-BRAF Fusion

Paton, D.J.W., Wong, D., Amanuel, B., Cheah, K. and Ardakani, N.M. (2021) S100/CD34-Positive Spindle Cell Mesenchymal Neoplasm Harboring KIAA1549-BRAF Fusion. The American Journal of Dermatopathology, 43 (3). pp. 217-220.

Link to Published Version: https://doi.org/10.1097/DAD.0000000000001796
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Abstract

Mesenchymal neoplasms with oncogenic kinase activity due to genomic alterations in receptor tyrosine kinase genes are a morphologically heterogeneous group with a variable biologic potential. A subset of these neoplasms are characterized by immunophenotypic property of dual S100 protein/CD34 expression, histopathological resemblance to lipofibromatosis or peripheral nerve sheath tumors, and often alterations in neurotrophic tropomyosin-related kinase genes. In this article, we present a case of an S100 protein/CD34-positive spindle cell neoplasm harboring a rare BRAF gene rearrangement (KIAA1549-BRAF fusion) and discuss the clinical, histopathological, and molecular variations associated with such neoplasms.

Item Type: Journal Article
Murdoch Affiliation(s): School of Veterinary and Life Sciences
Publisher: Wolters Kluwer
Copyright: © 2020 Wolters Kluwer Health, Inc.
URI: http://researchrepository.murdoch.edu.au/id/eprint/60056
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