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Dissecting lipid metabolism alterations in SARS-CoV-2

Casari, I., Manfredi, M., Metharom, P. and Falasca, M. (2021) Dissecting lipid metabolism alterations in SARS-CoV-2. Progress in Lipid Research, 82 . Art. 101092.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that has infected over sixteen million people globally. There have been more than two million deaths recorded worldwide, with no end in sight until a vaccine is developed. Current research has centred on different aspects of the virus interaction with cell surface receptors, but more needs to be done to further understand its mechanism of action in order to develop a targeted therapy and a method to control the spread of the virus. Lipids play a crucial role throughout the viral life cycle, and viruses are known to exploit lipid signalling and synthesis to affect host cell lipidome. Emerging studies using untargeted metabolomic and lipidomic approaches are providing new insight into the host response to COVID-19 infection. Indeed, metabolomic and lipidomic approaches have identified numerous circulating lipids that directly correlate to the severity of the disease, making lipid metabolism a potential therapeutic target. Circulating lipids play a key function in the pathogenesis of the virus and exert an inflammatory response. A better knowledge of lipid metabolism in the host-pathogen interaction will provide valuable insights into viral pathogenesis and to develop novel therapeutic targets.

Item Type: Journal Article
Murdoch Affiliation(s): Health Futures Institute
Western Australian Centre for Thrombosis and Haemostasis (WACTH)
Publisher: Elsevier
Copyright: © 2021 Elsevier Ltd.
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