Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia

Mowlaboccus, S., Daley, D., Pang, S., Gottlieb, T., Merlino, J., Nimmo, G.R., George, N., Korman, T.M., Streitberg, R., Robson, J., Peachey, G., Collignon, P., Bradbury, S., Colombi, E., Ramsay, J.P., Rogers, B.A. and Coombs, G.W.ORCID: 0000-0003-1635-6506 (2020) Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia. International Journal of Antimicrobial Agents . Art. 106121.

Abstract

Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence types, the two isolates harboured an identical plasmid-encoded fosA4 gene. The fosA4 gene has previously been identified in a single clinical E. coli isolate cultured in Japan in 2014. Each fosfomycin-resistant isolate harboured two conjugative plasmids that possessed an array of genes conferring resistance to aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides and/or trimethoprim.

Item Type:	Journal Article
Murdoch Affiliation:	Medical, Molecular and Forensic Sciences
Publisher:	Elsevier
Copyright:	© 2020 Elsevier Ltd and International Society of Antimicrobial Chemotherapy.
URI:	http://researchrepository.murdoch.edu.au/id/eprint/57560

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