A new pair of HLA-C alleles, Cw* 12042 and Cw*1203, differing at the KIR-related dimorphism of codons 77-80

Vilches, C., Bunce, M., Dam, M. and Pablo, R. (1998) A new pair of HLA-C alleles, Cw* 12042 and Cw*1203, differing at the KIR-related dimorphism of codons 77-80. Tissue Antigens, 51 (1). pp. 101-105.

Abstract

A previously unknown HLA-C variant of the Cw*12 group was identified by PCR-SSP from genomic DNA of cell NDS-JD. Molecular cloning and nucleotide sequence analysis permitted the characterization of the complete coding region of this new allele, Cw*12042. The new variant differs from the recently reported Cw*12041 by two silent changes at exons 2 and 3, and from Cw*1203 by coding changes at codons 77 and 80. Cw*1203 (Ser-Asn) and Cw*12042 (Asn-Lys) constitute the second known example of HLA-C alleles only differing at the KIR-related dimorphism of residues 77–80. The new allele is associated in cell NDS-JD with the haplotype HLA-A*2403, Cw*12042, B*51, DRB1*1502, DRB5*0102, DQB1*0601, possibly related from the evolutionary aspect to the ancestral haplotype A*2402, Cw*1202, B*5201, DRB1*1502, DRB5*0102, DQBl*0601.

Item Type:	Journal Article
Publisher:	Blackwell Publishing
Copyright:	1998 Munksgaard
URI:	http://researchrepository.murdoch.edu.au/id/eprint/5741

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