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Identification of a new HLA-B*39 allele: HLA-B*3924

Cook, J.T., Day, S., Dunn, P.P.J., Welsh, K.I. and Bunce, M. (2000) Identification of a new HLA-B*39 allele: HLA-B*3924. Tissue Antigens, 56 (2). pp. 178-179.

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We have identified a new HLA-B*39 allele through polymerase chain reaction (PCR) using sequence-specific primers (SSP) and sequence-based typing of exons 2 and 3. This novel allele was identified in three HLA-identical siblings of Turkish origin. This allele only differs from HLA-B*3903 at a unique single nucleotide substitution (T for C) at position 365 in exon 3 which results in an amino acid change in codon 98 of methionine (ATG) to threonine (ACG). The sequencing enabled the development of a monospecific PCR-SSP reaction which can be used to discriminate between HLA-B*3924 and other B*39 alleles.

Item Type: Journal Article
Publisher: Blackwell Publishing
Copyright: 2000 Munksgaard
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