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Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety

Solah, V.A., Brand-Miller, J.C., Atkinson, F.S., Gahler, R. J., Kacinik, V., Lyon, M.R. and Wood, S. (2014) Dose–response effect of a novel functional fibre, PolyGlycopleX®, PGX®, on satiety. Appetite, 77 . pp. 74-78.

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The objective of this research was to determine the dose–response effects of a palatable, viscous and gel forming fibre, PolyGlycopleX® (PGX®), [(α-D-glucurono-α–manno-β-D-manno-β-D-gluco), (α-Lgulurono-β-D mannurono), (β-D-gluco-β-D-mannan)] on satiety, and to gain insight into the underlying mechanisms that lead to appetite inhibition. Healthy subjects (n = 10), aged between 20.3 and 29.2 years, consumed PGX®, in granular form at 2.5, 5.0 and 7.5 g, and a 5g inulin control, with a standard breakfast. The PGX® doses of 2.5 and 7.5 g mixed with water at the start of breakfast increased satiety (iAUC of 140.0 and 157.7, P = 0.025 and 0.001, respectively) compared to the control. The most effective dose (7.5g) was palatable and corresponded to a 34% increase in fullness, measured using a visual analogue scale and incremental area under the curve, and resulted in a delayed postprandial glycaemic response when compared with the control.

Item Type: Journal Article
Publisher: Elsevier
Copyright: © 2014 The Authors.
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