Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase
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Boughton, B.A.
ORCID: 0000-0001-6342-9814, Dobson, R.C.J., Gerrard, J.A. and Hutton, C.A.
(2008)
Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.
Bioorganic & Medicinal Chemistry Letters, 18
(2).
pp. 460-463.
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Abstract
Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and a potential antibiotic target. The enzyme catalyses the condensation of (S)-aspartate semi-aldehyde (ASA) and pyruvate to form dihydrodipicolinate. Constrained diketopimelic acid derivatives have been designed as mimics of the acyclic enzyme-bound condensation product of ASA and pyruvate. Several of the compounds are shown to be active, slow-binding inhibitors with improved inhibition of DHDPS.
| Item Type: | Journal Article |
|---|---|
| Publisher: | Elsevier |
| Copyright: | © 2007 Elsevier Ltd |
| URI: | http://researchrepository.murdoch.edu.au/id/eprint/56485 |
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