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Synthesis and biological evaluation of triazolylnucleosides as antibacterial and anticancer agents

Ankit, ., Wang, T., Veedu, R.N., Abdmouleh, F., Arbi, M.E. and Kumar, S. (2020) Synthesis and biological evaluation of triazolylnucleosides as antibacterial and anticancer agents. Chemical Data Collections, 28 . Art.100429.

Link to Published Version: https://doi.org/10.1016/j.cdc.2020.100429
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Abstract

A series of novel triazolylnucleosides has been efficiently synthesized (6a-h, 7a-b) by azide–alkyne 1,3-dipolar cycloaddition reaction and evaluated for antibacterial and anticancer activities. These nucleosides (6a-h) were screened against Staphylococcus aureus (ATCC 6538), gram-positive and Escherichia coli (ATCC 10536), Salmonella and Pseudomonas gram-negative bacterial strains. Among the series, three compounds (6c-e) exhibited significant levels of antibacterial activity against Staphylococcus aureus in reference to the standard drug, Levofloxacin. Triazolylnucleosides (6a-h) were also screened for anti-proliferative activities against cancer cell lines such as Huh-7 liver cancer cells. Three compounds (6e, 7a-b) have displayed promising anti-proliferative activity against Huh-7 and U87G cancer cells lines.

Item Type: Journal Article
Murdoch Affiliation: Centre for Molecular Medicine and Innovative Therapeutics (CMMIT)
Publisher: Elsevier B.V.
Copyright: © 2020 Elsevier B.V.
URI: http://researchrepository.murdoch.edu.au/id/eprint/56366
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