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Human milk immunomodulatory proteins are related to development of infant body composition during the first year of lactation

Gridneva, Z., Lai, C.T., Rea, A., Tie, W.J., Ward, L.C., Murray, K., Hartmann, P.E. and Geddes, D.T. (2020) Human milk immunomodulatory proteins are related to development of infant body composition during the first year of lactation. Pediatric Research .

Link to Published Version: https://doi.org/10.1038/s41390-020-0961-z
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Abstract

Background
To investigate relationships between infant body composition (BC) and human milk (HM) immunomodulatory proteins (IMPs) during the first 12 months of lactation.

Methods
BC of breastfeeding dyads (n = 20) was measured with ultrasound skinfolds (infants) and bioimpedance spectroscopy (infants/mothers) at 2, 5, 9, and/or 12 months post partum. Breastfeeding frequency, 24-h milk intake, and IMP concentrations (lactoferrin, lysozyme, secretory immunoglobulin A (sIgA)) were measured, and calculated daily intakes (CDIs) were determined. We used linear regression/mixed-effects models and adjusted results for multiple comparisons.

Results
No associations were seen between maternal characteristics and IMP concentrations/CDIs or between IMP concentrations and infant BC. Lactoferrin CDI was negatively associated with infant fat-free mass index (P = 0.002); lysozyme CDI was positively associated with infant fat mass (P = 0.004) and fat mass index (P = 0.004) measured with ultrasound skinfolds.

Conclusion
In this small cohort of infants breastfed on demand during first year of life, we report differential associations of HM IMPs with infant BC, showing that in addition to their critical role in shaping infant immunity, lactoferrin, and lysozyme also influence development of infant BC, highlighting the importance of breastfeeding for 12 months and beyond.

Publication Type: Journal Article
Murdoch Affiliation: Information Technology, Mathematics and Statistics
Publisher: Lippincott Williams & Wilkins Ltd
Copyright: © 2020 Springer Nature Limited
URI: http://researchrepository.murdoch.edu.au/id/eprint/56184
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